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Indian Pediatr 2009;46: 822 |
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K Rajeshwari
Email:
[email protected]
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Recommendations for influenza vaccines
(MMWR Recomm Rep 2009; 58(RR8): 1-52). |
The 2009 seasonal influenza recommendations state that annual vaccination
be administered to all children aged 6 months-18 years for the 2009-10
influenza season; and vaccines containing the 2009-10 trivalent vaccine
virus strains A/Brisbane/59/2007 (H1N1)-like, A/Brisbane/10/2007
(H3N2)-like, and B/Brisbane/60/2008-like antigens be used. Vaccination
efforts should begin as soon as vaccine is available and continue through
the influenza season. Approximately 83% of the United States population is
specifically recommended for annual vaccination against seasonal
influenza; however, <40%received the 2008-09 influenza vaccine.
Comments These recommendations are available at CDC’s influenza
website (http://www.cdc.gov/flu). Vaccination and health-care providers
should be alert to announcements of recommendation updates.
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Emerging Artemisinin resistance in Asia
(N Engl J Med 2009; 361; 455-67). |
Artemisinin-based combination therapies are the recommended
first-line treatment of falciparum malaria in all countries with endemic
disease. There are recent concerns that the efficacy of such therapies has
declined on the Thai–Cambodian border, historically a site of emerging
antimalarial-drug resistance. In two open-label, randomized trials, the
efficacies of two treatments for uncomplicated falciparum malaria in
Pailin, western Cambodia, and Wang Pha, northwestern Thailand were
studied. Recrudescence confirmed by means of polymerase-chain-reaction
assay occurred in 6 of 20 patients (30%) receiving artesunate monotherapy
and 1 of 20 (5%) receiving artesunate–mefloquine therapy in Pailin, as
compared with 2 of 20 (10%) and 1 of 20 (5%), respectively, in Wang Pha.
Comment Signs that the efficacy of artemisinin-based
combination therapy and artesunate
monotherapy are declining can be disastrous for global malaria control.
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Good maternal diet prevents childhood
ALL (Public Health Rep 2009; 124:503-14). |
Maternal diet may play an etiologic role in acute lymphoblastic leukemia
(ALL), a common childhood cancer. Expanding on previous findings from
phase 1 of the Northern California Childhood Leukemia Study (NCCLS), a
population-based case-control study, it was attempted to further elucidate
and replicate the relationships between maternal diet and ALL risk. In 282
case-control sets of children (205 pairs and 77 triplets) from the NCCLS,
risk of ALL was inversely associated with maternal consumption of
vegetable (OR: 0.65, 95% CI: 0.50, 0.84); protein (OR: 0.55, 95% CI; 0.32,
0.96); fruit (OR: 0.81, 95% CI: 0.65, 1.00); and legumes (OR: 0.75, 95% CI
0.59, 0.95). The risk reduction was strongest for consumption of the
protein sources and vegetable food groups, independent of the child’s diet
up to age 2 years.
Comment It may be prudent for women to consume a
diet rich in vegetables and adequate in protein prior to and during
pregnancy as a possible means of reducing childhood ALL risk in their
offspring.
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Synbiotics do not help in severe
malnutrition (Lancet 2009; 374:136-44). |
The aim of this double-blind, randomized, placebo-controlled trial study
was to assess the clinical and nutritional efficacy of a probiotic and
prebiotic functional food for the treatment of severe acute malnutrition
in 795 Malawian children (age range 5 to 168 mo). After stabilization with
milk feeds, children were randomly assigned to ready-to-use therapeutic
food either with (n=399) or without (n=396) Synbiotic 2000
Forte (lactic acid bacteria) for the duration of treatment (median 33
days). Nutritional cure and secondary outcomes were similar in both
Synbiotic and control groups.
Comments Addition of synbiotics does not improve the outcome of
severe acute malnutrition.
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