The article was originally submitted as "Fluorosis and Diabetes Insipidus: A rare association". The article was processed for review to 3 referees as per the practise of the editorial office. One of the reviewer suggested to change the name of the title to "Fluorosis-A Complication of Diabetes Insipidus". For scientific excellence, it is customary that the authors are expected to incorporate the suggestions of the experts/ reviewers of that particular article. Hence the correction in the title as the complication. We the authors do understand the correct meaning of the term "complication"
and we agree
in toto
that in this article the
term complication is very appropriate as suggested by our lamed reviewer. The cause and effect relationship has been well discussed in the discussion.
Dr. Srivastava objects to the use of the statement "Further, severe crippling deformities due to skeletal fluorosis have not been reported in the literature to the best of our knowledge". We humbly wish to point
out that this particular sentence is in connection with fluorosis and diabetes insipidus. It follows the previous statement of dental fluorosis as a complication of diabetes insipidus described in literature only in 3 families. Despite exhaustive (and not elementary as mentioned in the letter) search to date we have not come across documented proof of skeletal fluorosis with crippling deformities in fluorosis associated with diabetes insipidus and hence the terms "to the best of our knowledge" which is not wrong at all. The issue here is of crippling deformities due to fluorosis in relation to diabetes Insipidus. No one is doubting about the classical presence of bony deformities in endemic fluorosis.
Further, involvement of skeletal system is normally seen with fluorine
content of water exceeding 8 ppm as per correlation of concentration
of fluoride to the biological effects. We have discussed this aptly in
the 'Discussion'.
Meenakshi N. Mehta,
9, Shaivali, C/3, BMC Colony,
K.A.G. Khan Road,
Worli, Bombay
400 018, India.