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Indian Pediatr 2011;48:
814 |
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Trends of Childhood Vasculitides in Eastern
India |
Sumantra Sarkar, Rakesh Mondal, Madhumita Nandi and Alakendu Ghosh*
Pediatric Rheumatology Clinic, Departments of Pediatrics
and *Medicine,
Institute of Post Graduate Medical Education
and Research, Kolkata, India.
Email: [email protected]
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A prospective follow up for 7 years (2004-2010) revealed 10.2% children
(n=158) had vasculitis among all rheumatological cases (n=1544).
Henoch-Schonlein Purpura (HSP) (56.9%) and Kawasaki disease (KD) (24%)
were major groups.
Key words: Childhood vasculitides, India.
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We, at our pediatric rheumatology clinic, IPGMER, Kolkata, diagnosed and
prospectively followed up children with different types of vasculitis for
a period of 7 years from 2004 to 2010. The objective was to delineate the
clinical spectrum of childhood vasculitis from Eastern India and to
explore the differences in disease pattern from that already reported. Out
of total 1544 rheumatological cases under12 years, 158 children had some
form of vasculitis according to American College of Rheumatology (ACR) and
Chappell Hill Consensus Criteria (CHCC).Nineteen cases were lost to
follow-up. Admission was required for 106 patients and 54 had serious
illness. Nine patients died. Primary vasculitides were diagnosed in 135
patients. Male: female ratio was 1.9:1 and the mean age of onset was 5.5
years. Kawasaki disease and Henoch-schonlein purpura was diagnosed in 38
(24%) and 90 (56.9%) cases, respectively. Other vasculitides included
Polyarteritis nodosa (n=4), Wegener’s granulomatosis (n=2),
and Takayasu disease (n=1). Secondary vasculitis accounted for 23
cases. HSP remains the most frequent vasculitis in our study, as also seen
in other studies [1,2] .
Sixteen of them (18%) had major organ involvement and 7 (7.77%) had
gastro-intestinal affection. Nine patients had isolated renal involvement.
Among the 38 cases of KD, 20 had coronary artery involvement, 5 had
persistent aneurysms, 29 received IVIG, none required angioplasty, and the
mortality was nil. One had incomplete KD, and atypical presentation with
renal failure was found in one.
TABLE I Spectrum of Vasculitis – Comparative Data in Different Series
Vasculitis |
Czeck series [4] |
Canadian series [2] |
US series [3] |
Indian data [9] |
Present series |
Types |
(n=452) |
(n=225) |
(n=434) |
(n=1064) |
(n=158) |
|
cases (%) |
cases (%) |
cases (%) |
cases (%) |
cases (%) |
KD |
23 (5.08) |
147 (65.3) |
97 (22.4) |
5 (0.46) |
38 (24.0) |
HSP |
410 (89.51) |
38 (16.9) |
213 (49.1) |
232 (21.8) |
90 (56.9) |
WG |
1 (.002) |
5 (2.2) |
6 (1.4) |
147 (13.8) |
2
(1.26) |
PAN |
1 (.002) |
4 (1.8) |
14 (3.2) |
94 (8.8) |
4 (2.53) |
TD |
1 (.002) |
2 (0.9) |
8 (1.8) |
215 (20.2) |
1 (0.63) |
Behcet’s |
– |
2 (0.9) |
– |
145 (13.6) |
– |
Miscl |
16 (3.53) |
27 (12) |
96 (22.1) |
226 (10.36) |
23 (14.55) |
KD: Kawasaki disease; HSP: Henoch-Schonlein purpiura; WG-Werner’s
granulomatosis: PAN-Polyarteritis nodosa; TD-Takayasu disease. |
Large studies with uniform comprehensive data are not
available from Asia. Indian data that included adult population is not a
true representation of pediatric vasculitides from all over the country
[4]. Our report is an attempt to document etiology of vasculitides in
Eastern part of India.
Contributors: RM, SS and MN were involved in
concept of the study and data acquisition and analysis. SS, RM drafted the
article and searched the literature. RM and AG did the critical review.
All the authors approved the final manuscript. RM will act as guarantor.
Funding: None.
Competing interests: None stated.
References
1. Bowers S, Roettcher P; Pediatric rheumatology clinic
population in the United States: results of a three year survey. J
Rheumatol. 1996;23;1968-74.
2. Dolezalova P, Telekesova P, Nemcova D, Hoza J.
Incidence of vasculitis in Children in the Czech Republic:2-year
prospective epidemiology survey. J Rheumatol. 2004 ;31:2295-9.
3. Kumar L, Singh S. Vasculitis in children. Indian J
Pediatr. 1996;63:323-34.
4. Joshi VR, Mittal G. Vasculitis - Indian perspective. JAPI.
2006;54;12-4.
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