1. Authors did not mention the gestational age of the study subjects. It is important to ascertain gestation before diagnosing neonatal encephalopathy as the recently proposed definition [3] is applicable for neonates born at or above 35 weeks. Also, the case definition of neonatal encephalopathy is not clearly stated in this paper.

2. The authors did not provide any reference for defining hypoglycorrhachia, increased protein and pleo-cytosis in cerebrospinal fluid. The cut-offs used are quite different from those proposed by National Neonatology Forum [4], and again are dependent upon the gestational age of the neonate. These arbitrary cut-offs may lead to bias in diagnosing meningitis..

3. This study highlights the neurotropism of Chikungunya infection, which again reminds of the Zika virus. Traditionally Chikungunya virus is thought to be mild neurotropic but current series contradict this hypothesis as all were having neurological features at presentation and two-thirds had persistent radiological findings. As highlighted by Dr. John in his editorial [2], both Chikungunya and Zika virus are transmitted by the same mosquito; and many times co-exists. Also, their coexistence may increase the virulence of each other. A recently published study showed that there is a strong significant correlation between the distribution of infection-related microcephaly and Chikungunya infection rate [5]. Therefore, it may be worthwhile to re-examine the birth/admission head circumference of the enrolled neonates for assessment of microcephaly and to look for an association, if any. Although, the number is small but still it can point towards a new hypothesis and may help in understanding the relation between microcephaly, poverty and co-infection of Zika, Chikungunya and other arboviruses.