Letters to the Editor Indian Pediatrics 2001; 38: 561-562 |
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Clinico-Virological Profile of Acute Flaccid Paralysis at a Referral Hospital |
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Thirty children fulfilling the criteria of AFP were evaluated(1,2). About 2/3rd were <5 years of age. Almost 1/3rd had received intra-muscular injection prior to the onset of paralysis. Three or more doses of OPV were received by 76.6% children. In 3 children there was history of trauma preceeding the weakness. Wild polio virus was isolated in 2 cases (P1 in both), vaccine virus in 2 (P2 in one and P1 + P3 in another) and non-polio enteroviruses (NPEV) in 4. CSF showed albumino-cytological dissociation in 4 cases. Two children died. Eleven had residual paralysis on 60 days follow up. Two children in whom wild polio virus was isolated did not have classicial clinical picture of polio at presentation(3) and did not have residual weakness at 60 days follow-up. It is possible that these two children had just infection with wild polio virus which did not produce the disease. Wild virus was not isolated in any of the 11 children with residual paralysis. In conclusion, AFP can be caused by disease other then polio and residual paralysis at 60 days follow-up can be due to causes other than polio.
Authors wish to thank Dr. A.K. Gurha, Suveillance Officer, Jabalpur and staff of NPSP, Jabalpur for their help.
R. Kumar,
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