We read with interest the study on epidemic of
Reye’s syndrome(1) and would like to report an interesting
epidemiological correlation of the syndrome. During the months of
October and November 1999, we had encountered fourteen cases of
Reye’s syndrome in Bijnor, a small district of western U.P.
situated around 150 km north of Delhi. The district has the
dubious distinction of having reported maximum number of paralytic
poliomyelitis cases in the country during the current year.
Further, it had also witnessed epidemics of viral encephalitis and
falciparum malaria from August to November this year. Majorities
of the cases of both diseases were confined to the villages and
towns situated in and around ‘Kho River’, a large pool of
stagnant water, known for high density of mosquito population. The
exact etiology of the cases of viral encephalitis could not be
established owing to non availability of facilities of viral
isolation and serological testing. Though the occurrence of
Japanese encephalitis in the region
is not common, the environmental factors strongly favor its
presence in the community. Interestingly, twelve (86%) out of
fourteen children with Reye’s syndrome belonged to the same
geographic area which harbored the above-mentioned epidemics.
In our series of fourteen cases of ‘Reye’s
syndrome’, the diseased children were from two to fourteen years
old and most had rural background. Both the sexes were equally
affected. In one case, the older sib had also died of similar
illness three days earlier. One child had history of jaundice with
unconsciousness two years back. None of the children was given
aspirin or any other medicine containing salicylates.
The following clinical criteria were used to
diagnose cases of ‘Reye’s syndrome’: (i) Rapid onset of
unconsciousness after a short history of fever and vomiting; (ii)
Absence of significant fever and jaundice at the time of
presentation; (iii) Four to six folds rise in liver enzyme levels
(100%), and low serum glucose levels (79%); (iv) Normal
cerebrospinal fluid examination; and (v) Absence of malaria
parasite from peripheral blood smear examina-tion. Liver biopsy
could not be performed due to deranged coagulation profile, and
low general condition of the cases. Six (43%) out of fourteen
children expired, two (14.3%) recovered and rest (43%) were
referred to higher centers. Unlike the study from Chandigarh(1),
DDT in place of Malathion is usually used as an anti-mosquito
measure in this region.
Reye’s syndrome is an encephalopathy of
uncertain etiology. A number of diseases may present a clinical
picture resembling Reye’s syndrome. Various viral infections
like vari-cella, measles, influenza A and B, adenoviruses have
been implicated as cofactors in the pathogenesis of the
syndrome(2). The presence of all the three illnesses in the same
geographic area, which harbors a high density of mosqui-toes,
points to some interesting causative mechanism in the evolution of
‘Reye’s syndrome’. Since the vectors of both falciparum
malaria and Japanese encephalitis virus are mosquitoes, can a
micro-organism (probably a viral agent), transmitted by a vector
(mosquito) be responsidble for priming of liver which later on
ingestion of certain drugs (salicylates or other agents) trigger
events that lead to the development of full blown features of ‘Reye’s
syndrome’? We need more epidemiological studies to confirm this
association apart from identifying the exact arthropod borne
pathogen.
Vipin M. Vashishtha,
Mangla Hospital, Shakti Chowk,
Bijnor 246 701, India.
E-mail: [email protected]
J.P. Sharma,
District Hospital
Bijnor 246 701, India.
References
1. Ghosh D, Dhadwal D, Aggarwal A, Mitra S,
Garg SK, Kumar R et al. Investigation of an epidemic of Reye’s
syndrome in Northern Region of India. Indian Pediatr 1999; 36:
1097-1106.
2. Balistreri WF. Reye syndrome and "Reye-like"
diseases. In: Nelson Textbook of Pediatrics, 15th edn. Eds.
Behrman Re, Kliegman RM, Arwin AM. Philadelphia, W.B. Saunders,
1996; pp 1144-1145.
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