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Indian Pediatr 2011;48:
249 |
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Re-evaluation of Congenital Hypothyroidism |
P Ramesh Menon and K Rajmohan
Department of Pediatrics, Government TD Medical College, Alappuzha, Kerala, India.
Email: [email protected]
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I read with much interest the work done by Nair, et al. [1] in
evaluating children with congenital hypothyroidism and the effect of
stopping/withholding thyroxine by 3 years of age. I would like to
highlight that with a smaller sample and non-normal distribution of data,
reporting of medians may be more relevant, as in the case of age at
diagnosis. In addition, since repeated measurements of TSH, T4 and T3 were
available, repeated measures analysis of variance (RMANOVA), would have
been a more appropriate test to be used. If the assumption of fixed
interval between repeated measures is violated or differences are
non-normal, Friedman test may be applied. The conclusions drawn that
permanent and transient hypothyroidism had significantly different TSH
values to begin with and different dosing requirements of thyroxine may
still be valid and biologically plausible.
Reference
1. Nair PS, Sobhakumar S, Kailas L. Diagnostic re-evaluation of
children with congenital hypothyroidism. Indian Pediatr. 2010;47:757-60.
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