1. A very wide range in the incidence of meconium
aspiration syndrome (MAS) from 1.62% to 34.4% has been reported in
the literature [1-3]. We could not find the incidence of MAS in the
vigorous infants only, and thus, we decided to go by the incidence
(15%) observed in our institution. Another reason of considering our
own institutional incidence of MAS was similar demographic profile
of the mothers and infants.
2. A vigorous infant was defined at birth as:
spontaneous breathing/crying; HR >10 in 6 seconds; and good muscle
tone. All infants were monitored by Downe’s scoring for the
development of respiratory distress after birth until 72 hrs of age;
the first assessment was done at 30-45 min of age. Infants who
developed dyspnea during this period and had radiological evidence
of meconium aspiration were diagnosed as MAS.
3. Intestinal peristalsis might be affected in
the infants born to mothers receiving methyldopa as
anti-hypertensive medication. Therefore, these infants were excluded
from this study where feed intolerance was being studied.
4. Meconium-stained amniotic fluid (MSAF) may be
aspirated in utero in the majority of cases. However, it can
also be aspirated after birth when an infant vomits out meconium
stained liquor causing secondary MAS. The definition of MAS includes
respiratory distress, radiological evidence of meconium aspiration
and birth through MSAF. All infants who aspirate meconium do not
develop MAS and we agree that in an asymptomatic infant there is no
need to do X-ray chest. But our premise is that gastric
lavage will prevent development of secondary MAS where meconium is
aspirated after birth. The X-ray chest was, therefore, done
in this study within 4 hrs in all infants to document any
radiological evidence of the intrauterine aspiration of MSAF.