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Indian Pediatr 2018;55: 6 17-618 |
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Gastric Lavage in Infants Born with Meconium Stained Amniotic
Fluid: Few Concerns
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Sankalp Dudeja1
and Tapas Bandyopadhyay2
1Division of Neonatology, Department of Pediatrics, PGIMER,
Chandigarh and 2Department of Neonatology, PGIMER and Dr.RML
Hospital, New Delhi; India.
Email:
[email protected]
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We read with interest the article by Gidaganti, et al. [1]
published recently in Indian Pediatrics, which concluded that
gastric lavage does not reduce either meconium aspiration syndrome (MAS)
or feed intolerance in vigorous infants born through meconium stained
amniotic fluid (MSAF).
The practice of gastric lavage in babies born through
MSAF is being followed at many centers. A recent systematic review by
Deshmukh, et al. [2] concluded that routine gastric lavage may
improve feed tolerance in neonates born through MSAF. However, well
designed studies are still needed to confirm these findings. This trial,
therefore, was need-based and addressed this clinically relevant issue.
We would like to highlight a few important issues:
1. For sample size calculation, the authors have
assumed the incidence of MAS in babies born with MSAF as 15%, based
on an old unpublished study. However, most of the recent studies
have reported the incidence of MAS as 5-8% [3,4]. Moreover, in the
present study itself, the incidence of MAS is quite less (1.4% in
intervention arm and 2.2% in control arm). The authors should have
used information from these studies to calculate the sample size for
adequate power of their study.
2. We clearly miss the definition of ‘vigorous
infant’ in the entire manuscript. Also, whether the authors also
included babies with respiratory distress soon after birth is not
clear.
3. One of the exclusion criteria mentioned in the
methodology is; mothers receiving methyldopa. It is not clear why
these babies were specifically excluded.
4. In this study, chest X-ray was done in
all participants within 4 hours of birth, irrespective of symptoms.
We feel that doing X-ray in an asymptomatic baby is not
ethically justified. Also, MAS is defined based on presence of
clinical symptoms and abnormal chest X-ray. Chest X-ray
could have been done only in babies with respiratory distress.
5. For lavage, normal saline (10mL/kg) was used.
As lavage was done before the baby was weighed, the clinician must
have used approximations to estimate birth weight. It would have
been better if volume used for lavage was weight independent.
6. Apart from the adverse effects studied,
another potential harm of this intervention is being an hindrance to
routine care. If, not for this intervention, a vigorous baby born
through MSAF would have received immediate skin to skin contact and
early initiation of breastfeeding. However, the need to perform
gastric lavage before feeding hinders this practice. This adverse
effect of performing this procedure should appear in the manuscript.
References
1. Gidaganti S, Faridi MMA, Narang M, Batra P. Effect
of gastric lavage on meconium aspiration syndrome and feed intolerance
in vigorous infants born with meconium stained amniotic fluid – A
randomized control trial. Indian Pediatr. 2018;55:206-10.
2. Deshmukh M, Balasubramanian H, Rao S, Patole S.
Effect of gastric lavage on feeding in neonates born through meconium-stained
liquor: A systematic review. Arch Dis Child Fetal Neonatal Ed.
2015;100:F394-9.
3. Fischer C, Rybakowski C, Ferdynus C, Sagot P,
Gouyon J-B. A population-based study of meconium aspiration syndrome in
neonates born between 37 and 43 weeks of gestation. Int J Pediatr.
2011;2012.
4. van Ierland Y, de Boer M, de Beaufort AJ. Meconium-stained
amniotic fluid: discharge vigorous newborns. Arch Dis Childhood-Fetal
Neonatal Ed. 2010;95:F69-71.
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