I read with interest the recently published article
in Indian Pediatrics reporting the association between
hematological indices and serum uric acid in adolescents with
hyperuricemia [1]. Serum uric acid levels were found to be correlated
with white and red blood cell count, hematocrit, and hemoglobin in
adolescents with hyperuricemia. However, some issues need clarification:
First, in the original study, it was stated that
hyperuricemia was defined as serum uric acid level >5.5 mg/dL and the
same level was used as an inclusion criteria for adolescents aged
between 11 and 21 years. Moreover, majority (78%) of 607 adolescents
were boys. Reference values of serum uric acid are different, based on
age and gender [2-5]. The use of this single value (>5.5 mg/dL) for the
diagnosis of hyperuricemia does not seem appropriate. Second, it is
stated that diabetes mellitus and hypertension were used as exclusion
criteria in the original study. However, it is also indicated that 187
(31 %) of adolescents had metabolic syndrome (MetS). This seems to be
contradictory.
References
1. Stelmach MJ, Szczerbinski L, Wasilewska N, Protas
P, Wasilewska A. Hematological parameters in adolescents with
hyperuricemia. Indian Pediatr. 2014;51:1003-5.
2. Tomczak J, Wasilewska A, Milewski R. Urine NGAL
and KIM-1 in children and adolescents with hyperuricemia. Pediatr
Nephrol. 2013;28:1863-9.
3. Sertoglu E, Ercin CN, Celebi G, Gurel H, Kayadibi
H, Genc H, et al. The relationship of serum uric acid with
non-alcoholic fatty liver disease. Clin Biochem. 2014;47:383-8.
4. Mayo Clinic, Mayo Medical Laboratories, Test
Catalog. Uric Acid, Serum. Available from: http://www.
mayomedicallaboratories.com/test-catalog/Clinical+ and+Interpretive/8440.
Accessed February 12, 2015
5. Kayadibi H, Sertoglu E, Uyanik M. Importance of
the selected cut-offs for serum uric acid and lipids levels. Scientific
World J. 2014;2014:746561.