Locked in syndrome (LIS) is a neurological syndrome in which despite being conscious patient is unable to communicate [4]. It is rarely reported in snake bite [5,7]. We report 4 children with LIS following snake bite.

Case 1: A 2-year-old child presented with bleeding from ear, followed by altered sensorium and respiratory failure within two hours of initial complaints. At admission, child had respiratory arrest with severe bradycardia, absent peripheral and central pulses, and Glasgow coma scale (GCS) score of 3; pupils were fixed and dilated and doll’s eye movements were absent. After initial resuscitation, he was noted to have some movement of right toe. Seven hours later, snake bite was suspected and polyvalent anti-snake venom (ASV) was administered. Thirty hours later, after receiving 25 vials, child had spontaneous respiration, movements of lower limbs and eye opening but pupils were still fixed and dilated. Pupillary reactions became normal on day three, doll’s eye movement appeared a day later, and the child was discharged in premorbid condition on day ten.

Case 2: A-ten-year-old boy presented with history of anxiety, pain abdomen and vomiting appearing acutely early morning, while sleeping on the floor of his cottage. His sister had died an hour back with similar complaints. Parents did not report any venomous bite. At admission, he had bradycardia, gasping respiration and GCS of 3. Pupils were fixed and dilated and doll’s eye movement were absent. He was put on respiratory support. There was no improvement over next 48 hours. Detailed examination revealed fang marks on one foot so ASV was given. On day six, parents noted fluttering of eyelids and next day he had spontaneous respiration and limb movements. After one week, doll’s eye movements appeared but internal ophthalmoplegia persisted. CT head was normal and fundus examination did not show features of optic neuritis. At discharge, five weeks later, internal ophthalmoplegia was persisting.

Case 3: A One-and- half-year old child with history of snake bite presented to the emergency department with breathing difficulty. At admission, she had gasping respiration, bradycardia, GCS of 3, fixed dilated pupils and absent Doll’s eye movement. There was no response to ASV. After 36 hours, she started having spontaneous respiration and occasional movement of limbs. She used to cry on looking at parents. On day four, pupillary size and reaction became normal. She was discharged on day 10 in premorbid condition.

Case 4: A Seven-year-old boy presented with history of sudden onset of pain abdomen and vomiting, while in the playground. At admission, he had gasping respiration. Two hours later, he was atonic, areflexic; pupils were fixed and dilated with absent doll’s eye movements. After ruling out other causes (normal cerebrospinal fluid examination, CT head, and liver function tests); possibility of snake bite was entertained and ASV was given. After 10 vials of ASV, ptosis resolved and child started responding using eye movements; 25 vials later, spontaneous limb movements appeared but internal ophthalmoplegia persisted. Three weeks later, at discharge, internal ophthalmoplegia was persisting.

Neurotoxic manifestations of snake bite vary in severity but pediatric case reports of LIS due to snake bite are rare [7].

In LIS, patient is conscious yet unable to communicate. It can be of three types: classic, in which patient has quadriplegia and anarthria with preservation of consciousness and vertical eye movements. Incomplete LIS is similar to classic except remnants of voluntary movement other than vertical eye movement are present. In total LIS, there is total immobility and inability to communicate, with preserved consciousness [4]. Usual causes of LIS are stroke, trauma or encephalitis of ventral pontine area but it can also be caused by extensive bilateral destruction of corticobulbar and corticospinal tracts in the cerebral peduncles [8]. LIS can also be caused by peripheral causes such as severe Guillan-Barre’s syndrome, neuromuscular junction blockade (myasthenia gravis, toxins, snake bite), etc.

LIS in snake bite occurs due to neuromuscular paralysis of voluntary muscles which in turn is caused by neuromuscular transmission blockade (krait venom acts pre-synaptically while cobra venom acts post-synaptically) [2]. Irreversible binding of toxin to presynaptic portion makes clinical recovery slow in krait envenomation as recovery occurs only with the formation of new neuromuscular junctions [9], as was seem it our cases, especially case 2. Such long duration of LIS in snake bite is not reported previously. Duration of LIS varied from 30 hours to six days. In about 50% cases of LIS, it has been seen that family members are the first one to note that patient is able to communicate [10], as was seen in case 2.

Snake bite documentation was done only in one case by the caregivers, in the rest of the cases, clinical scenario was typical of painless krait bite [3]. Since differential diagnoses of unresponsive patient are exhaustive, high degree of suspicion is required in such cases, especially during rainy season. Fixed dilated pupils and absent doll’s eye movement can easily be interpreted as brain death, if possibility of LIS is not considered. Physicians need to be aware of likelihood of snakebite presenting as LIS, especially in the appropriate clinical setting.

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2. Warrell DA, International panel of experts. Guidelines for the Clinical Management of Snake Bite in the South-East Asia Region. Southeast Asian J Trop Med Public Health 1999, 30 (Supplement) 11-85: Available from http://www.searo.who.int/LinkFiles/SDE_mgmt_ snakebite.pdf. Accessed on August 15, 2012.

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6. Agarwal R, Singh N, Gupta D. Is the patient brain-dead? Emerg Med J. 2006;23:e5.

7. John J, Gane BD, Plakkal N, Aghoram R, Sampath S. Snake bite mimicking brain death. Cases J. 2008;1:16.

8. Smith E, Delargy M. Locked-in syndrome. BMJ. 2005:330;406-9

9. Woo LS, Chul JI, Hoon YY, Hyun HS, Su HK, Hyuk CS, et al. Anticholinesterase therapy for patients with ophthalmoplegia following snakebites: Report of two cases. J Korean Med Sci. 2004;19:631-3.