The Creation of Synthetic Life
Call him maverick scientist or genomic wizard – Craig
Venter is again in the headlines with another audacious feather in his
cap. Craig Venter became famous as the bad boy of genome research when he
first tried to patent a human gene more than a decade ago and then entered
into fierce competition with the publicly funded Human Genome Project to
be the first to decode the human genome.
Now scientists of the Craig Venter Institute in
Rockville, Maryland have created what is being touted as "synthetic life".
Actually, what Daniel Gibson and his colleagues have done is to
artificially manufacture the entire genome of the bacterium Mycoplasma
mycoides. They then transplanted it into the empty cell of a different
species M. capricolum which continued to survive and astonishingly
multiply. On replication it produced proteins of only M. mycoides.
To rephrase it, they rebooted a cell with the artificially created
software of another species. On repeated replication by the process of
"infinite dilution" eventually even the hardware has gotten replaced under
instructions of the new software.
What are the possible gains of being able to create
synthetic bacteria? First is the power to reduce environmental carbon
dioxide and return oxygen to the atmosphere. Others include mass
production of medicines and of course the creation of biofuels.
What could be the negative fallouts? ‘Bioerror’ and ‘bioterror,’
where new organisms either escape into the real world or are misused for
warfare are what the doomsayers are warning us about.
The single-celled organism has several "watermarks"
written into its DNA to identify it as synthetic and help trace its
descendants back to their creator, should they go astray. These watermarks
include email ids, website address and quotations. The three inspiring
quotes include one by the writer James Joyce ‘To live, to err, to fall, to
triumph, to recreate life out of life’; another from the biography of the
great scientist J. Robert Oppenheimer: "See things not as they are, but as
they might be". And from the mathematician Richard Feynman, who said:
"What I cannot build, I cannot understand" (www.naturenews.com 20 May
2010, The Hindu 3 June 2010, Gibson et al. Creation of a
bacterial cell controlled by a chemically synthesized genome, Science 20
May 2010).
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