In the recent report on Glucose-6-Phosphate Dehydrogenase (G-6-PD) deficiency in neonatal hyperbilirubinemia, 36% were females(1). Being an X-linked recessive disorder, females are very unlikely to be affected until either they are Turner genotype (XO) or both X-chromosomes in them are defective or normal X-chromosome is made inactive as per Lyon hypothesis. How do the authors explain this X-Linked recessive disorder manifesting in such a large proportion of girls?
 

Ravi Goyal,
581-A, Talwandi,
Kota - 324 005,
Rajasthan,
 India.
 

1. Kuruvilla KA, Sukumar ST, Jana AK. Glucose-6-Phosphate dehydrogenase deficiency in neonatal hyperbilirubinemia in a South Indian referral hospital. Indian Pediatr 1998; 35: 52-55.