Both cefpodoxime and cefixime (3rd generation oral cephalosporins) are not currently first line drugs for any pediatric illness. The only oral antibiotic combination with clavulinic acid that is listed in pediatric drug formularies is amoxiciilin with clavulinic acid. There are no RCT’s available to date that compares cefpodoxime and cefixime given alone with their respective combinations with clavulinic acid. Therefore, organisms resistant to these drugs, which must be used only as second or third line drugs, must be treated with broad spectrum antibiotics and not with their combination with clavulinic acid.