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Letters to the Editor

Indian Pediatrics 2005; 42:191-193

Presence of Thyroid Antibodies in a Child with Systemic Lupus Erythematosus


A 6-year-old girl presented with high grade fever daily and painful swelling of all major joints for two months. She had been treated with various anti inflammatory drugs and corticosteroids as a case of chronic arthritis without much relief. She was investigated in detail, diagnosed and con-firmed to have systemic lupus erythematosus (SLE) and lupus nephritis based on the following results obtained. Her laboratory investigations were total WBC count -12,100 /cu.mm, differential count-N 62%, E 2%, L 30%, M 6%, ESR 62 mm at 1 hr, Hb 10.5 g%, platelet count 3,92,000/cu mm, reticulocyte count 1.0%, blood picture aniso-cytosis with hypochromia. Her serum total complement was 40% and antinuclear anti-body (ANA) was positive. Her anti dsDNA antibody level was 51 AU/mL (normal <30 AU/mL). Renal biopsy showed lupus nephritis (WHO grade II). Her 24 hour urine protein excretion measured 16 mg in 790 mL. Her serum albumin was 3.8g%. All other investigations were within normal limits.

One month prior to the onset of these symptoms, she had thyroid function tests done elsewhere in view of the strong family history of hypothyroidism with the maternal grand-mother, uncle and aunt reportedly affected but whose further details were unknown. She did not have any goitre or features of hyper or hypothyroidism at that time. Her thyroid function tests then were reported to be as follows: serum triiodothyroxine (T3) 49 ng/dL (normal 70- 200), serum total thyroxine (T4) 2.77 µg/dL (normal 4-13) and serum thyroid stimulating hormone (TSH) 98.07 mIU/mL (normal 0.3- 6.0). She was started on thyroxine 100 micrograms once daily since then.

Thyroid function tests repeated by us while she was receiving thyroxine replace-ment therapy showed serum total T4 14.8 µg/dL, free thyroxine concentration (FT4 conc.) 2.00 ng/dL (normal 0.8-2.0) and TSH of 2.83 mIU/mL (normal 0.3-4.5). Her thyroid anti-body titers were: thyroglobulin hemag-glutination antibody (TGHA) 1:3202 and microsomal hemagglutination antibody (MHA) 1:1602 (significant titer >1:102). She was prescribed prednisolone and azathioprine for treatment of lupus nephritis. She was advised to continue thryroxine in replacement doses, in view of her high level of thyroid antibody status, strong family history and prior biochemical evidence of hypo-thyroidism. She was reviewed three months later, when the repeat thyroid function tests revealed T4 16.7 µg/dL, FT4 conc. 2.35 ng/dL and TSH of 0.678 mIU/mL after which thyroxine was stopped because of hyper-thyroxinaemia and severe TSH suppression. She was advised followup and monitoring of thyroid function tests to ensure euthyroid status or disordered thyroid function.

Even though high prevalence (32%) of antithyroid antibodies in children with SLE has been reported in the literature, thyroid dysfunction is rare (9%)(1). The corresponding figures in Miller series(2) were 25% and 7.5% and 43% and 18% respectively in the report by Eberbard, et al.(3).

B-lymphocyte dysregulation is the immunopathological explanation for the production of autoantibody and other antibodies in SLE. As in SLE, presence of antithyroid antibodies without any other biochemical evidence of thyroid disease has been documented in several other auto-immune endocrine diseases(4,5). Drugs used in the treatment of SLE such as glucocorticoids may either suppress serum T3 or T4 values or prevent the development of overt thyroid disease by anti-inflammatory action(3).

In the presence of high level of thyroid antibodies, diagnosis and treatment of thyroid abnormalities based exclusively on bio-chemical abnormalities in children with SLE require special attention and regular followup.

J. Julius Xavier Scott,
P. Raghupathy,

Department of Child Health Unit I,
Christian Medical College,
Vellore 632 004, Tamilnadu, India.
E-mail: [email protected]

 


1. Miller FW, Moore GF, Weintraub BD, Steinbeog AD. Prevalence of thyroid disease and abnormal thyroid function test results in patients with systemic lupus erythematous. Arthritis Rheum 1987; 30: 1124-1131.

2. Boey ML, Fong PH, Lee JS, NgWY, Thai AC. Autoimmune thyroid disorders in SLE in Singapore. Lupus 1993; 2: 51-54.

3. Eberbard BA, Laxer RM, Eddy AA, Silvermann ED. Presence of thyroid abnormalities in children with systemic lupus erythematous. J Pediatr. 1991; 119: 277-279.

4. Editorial. Autoimmune thyroid disease and thyroid antibodies. Lancet 1988; 1: 1261-1262.

5. Larson RA, Oodal T. Family studies in systemic lupus erythematosus, IX. Thyroid diseases and antibodies. J Chron Dis 1972; 25: 225-233.

 

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