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Indian Pediatr 2010;47:
1047-1050 |
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Steam Inhalation in Respiratory Illnesses -
Full Steam Ahead or Full Stop? A Systematic Review of
Randomized Controlled Trials |
Joseph L Mathew
Advanced Pediatrics Centre, PGIMER, Chandigarh 160 012,
India.
Email: jlmathew@rediffmail.com
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The clinical question in this EURECA is:
"Does steam inhalation (Intervention) result in clinical
improvement (Outcome) in people with respiratory illness (Population),
as compared to no steam inhalation/placebo (Comparison)? The
clinical conditions include upper (common cold, croup, sore throat) and
lower (bronchiolitis, pneumonia) respiratory tract illnesses.
Relevance
Steam inhalation is perhaps one of the most widely
prevalent home-based practices, amongst laity and the professionals; based
on the perception that warm humidified air provides subjective relief of
respiratory symptoms, by loosening the respiratory secretions(1). Advances
in understanding of pathophysiology of respiratory infections/illnesses
and development of specific therapy; make it important to examine this
age-old ‘remedy’ in the light of modern evidence-based health-care
practice.
Current Best Evidence
A Medline (through Pubmed) search updated on 25th
October 2010, using the term "steam" and Limits: Clinical trials,
randomized controlled trials and meta-analysis; short-listed 8
potentially relevant publications(1-8) including five relevant RCTs(2-6).
Simultaneous Cochrane Library search with the term "steam" and
filter "Record Title, Abstract or Keywords" yielded 4 Cochrane
Reviews(9-12), 1 Cochrane review protocol(13), and 103 Clinical Trials.
One Cochrane review(9) and the protocol(13) were relevant; two did not
deal with steam/heated humidified air inhalation(10,12), and one evaluated
steam in ventilated patients(11). No additional trials were identified.
Scanning reference lists of included publications yielded one more
trial(14). Thus a total of six trials were relevant to this review; five
evaluated steam in adults with common cold(2,3,5,6,14); only one trial was
conducted in children (with pneumonia or bronchiolitis)(4). This trial
lacked the methodological refinements of the other trials. Characteristics
of included studies are summarized in Table I.
Table I
Summary of RCTs Examining Steam Inhalation in Respiratory Illnesses
No |
Study
design |
n
(steam/control) |
Intervention |
Results |
Outcomes |
Ref |
1 |
DB, PC, RCT |
62 (32/30) |
Nasal inhalation of air at
42-44 C twice x 20 min versus air at 22-24 C |
Subjective response daily ×
7 dPeak nasal inspiratory and expiratory flow (patency) on d1,d2,d7 |
Subjective improvement :
26/32 vs 7/30 Increased nasal patency 61-74% vs 6-8%. |
2 |
2 |
DB, PC, RCT |
66 (32/34) |
Nasal inhalation of air at
40-42 C twice versus air at 20-24 C |
Subjective symptom scores
for nasal congestion, nasal drainage, and sneezing. Nasal resistance
using rninomanographer. |
Subjective improvement on
d7 : 24/32 vs 34/34Nasal resistance improvement 6% vs 11%.Side
effects 36% vs 9% |
3 |
3 |
DB, PC, RCT |
68 (32/36) |
Inhalation of air at 47 C ×
60 min to raise nasal temp to 43 C versus air at 20-24 C |
Subjective symptom scores
for nasal congestion, nasal drainage, and sneezing. objective
measures of nasal resistance |
No significant difference
in daily symptom scores. Improvement in nasal resistance favoring
placebo on d7 |
5 |
4 |
RCT |
20 |
Nasal inhalation of air at
42-44C at 24 and 48 hr after infection versus air at 22-24 C. |
Improvement in symptom
scores. Nasal washing viral titres (shedding) over 4 days |
Mean viral titres (/mL)
10(1.7) vs 10(1.8)
10(1.7) vs 10(1.9)
10(1.2) vs 10(1.6)
10(0.9) vs 10(0.7) |
6 |
5 |
RCT, DB |
96 (87 records available)
45/42 |
Nasal inhalation of air at
43C versus air at air at 30C. |
Subjective improvement
Proportion |
No difference in proportion |
14 |
6A |
RCT |
16 |
Steam inhalation within a
cloth tent versus no steam |
Respiratory status at 0,
6h, 48h |
In bronchiolitis, less time
for recovery and less duration of hospitalization |
4 |
6B |
same as above |
20 |
same as above |
same as above |
No difference in
improvement. |
4 |
DB=double blind, PC=placebo controlled, RCT=randomized controlled
trial. |
The Cochrane review on common cold(9) was updated till
May 2006; no additional trials are identified. Hence the data therein can
be considered current, but a few methodological errors necessitate a fresh
review.
Data from the common cold trials were heterogeneous (in
terms of participants, outcome measures, timing of measurement, and
baseline status. One trial(2) suggested subjective improvement with steam;
another(3) suggested the opposite and yet another showed no difference(5).
Meta-analysis did not show benefit (RR for non-improvement=1.78; 95%CI
0.01-226.51). The single trial in children with pneumonia showed no
benefit of steam, but some benefit in bronchiolitis(4). No data were found
pertaining to croup and sore throat. There was limited data on the adverse
events associated with steam inhalation especially the risk of
burns/scalds in infants and children.
Critical Appraisal
At first glance, this EURECA systematic review does not
appear to present significant new findings in terms of management, except
that there are no scientific grounds to encourage steam inhalation in
children. However, it presents the opportunity to critically appraise a
few important issues.
Is steam inhalation relevant in modern practice? It
must be noted that the practice of steam inhalation could have been
relatively justifiable at a time when there was limited understanding of
pathophysiologic mechanisms in various respiratory tract illnesses;
coupled with limited therapeutic options. Presently, both situations have
dramatically changed for most respiratory conditions.
Subjective versus objective improvement: It is
interesting that subjective improvement/perception of relief; often does
not correlate with objective measurements. This raises the tricky issue of
whether, ‘feeling better’ is superior to ‘being better’. In the context of
conditions as diverse as acute common cold to chronic arthritis, the
former cannot be ignored, and may take precedence over precise objective
measurements. On the other hand, for most other clinical conditions,
demonstration of subjective improvement may be inadequate to prove that an
intervention works. The precise balance between subjective and objective
outcome measures in common cold, is not clear. Moreover, the subjective
and objective outcome measures reported in adult studies are difficult to
replicate in children, necessitating less robust methods to evaluate
benefit. This could alter the results of pediatric trials significantly.
Is there any harm in recommending steam inhalation?
Many care-givers (physicians and parents) may prefer to opt in favour of
steam inhalation, based on personal (favourable) experiences, and might
argue that this outweighs the (absence of) data from research studies. It
must be emphasized that one of the goals of evidence-based health-care is
to protect patients from precisely this tendency.
Extendibility
Most of the included trials recruited adults, delivered
hot humidified air, through commercial devices and used complex objective
measurements. The lone pediatric trial was limited in terms of quality and
quantity, to draw a meaningful conclusion in favor of steam inhalation.
Hence strictly speaking, the data is not extendible to the population of
interest.
Funding: None.
Competing interest: None stated.
EURECA Conclusions in the Indian Context
• There is
not enough evidence supporting benefit of steam inhalation in acute
(upper and lower) respiratory illnesses in children.
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