Baboon syndrome (reminiscent of red bottom of the baboon) is a rare, prognostically benign and often under-diagnosed drug eruption with distinct clinical features. It presents as a systemic contact dermatitis with pruritic and confluent maculopapular light-red eruption, localized in the gluteal area and the major flexures, developing several hours or days after drug or agent contact. It is a type 4 immunologic reaction and SDRIFE (symmetrical drug related intertriginous and flexural exanthem) specifically refers to the distinctive clinical pattern of this drug eruption. Several drugs have been previously described as responsible for the syndrome e.g., mercury (the most frequently implicated), nickel, different antibiotics, heparin, aminophylline, pseudoephedrine, terbinafin and immunoglobulins.