We thank the authors for showing interest in our
article. The clarifications to the concerns raised are as follows:
1. In the ‘proven’ category of invasive fungal
infections, none of the isolate was Aspergillus. Fungi isolated from
blood were Candida albicans, Candida tropicalis, and
Trichosporon spp.
2. Out of 11 isolates from sputum, A.
fumigates was positive in seven and A. flavus was the
species in four patients. The antimicrobial sensitivity details are
not available.
3. The authors rightly stated that current
literature argues against cross-reactivity of Galactomannan (GM)
antigen test and the new EDTA-containing piperacillin/tazobactam
formulation. However, in low- and middle-income countries where
generic formulations are widely used, it remains a valid concern. A
recent study had shown that the rate of false positive serum GM
antigen test was as high as 56% in patients who received generic
preparation [1]. With standard brands, the association is no longer
applicable, but false positive can still be there with generic
medicines [2].
4. We agree that pulmonary leukostasis may lead
to a false impression of a fungal nodule or ground-glass opacities
on computed tomograph (CT) scan. In our study, three patients had
hyperleukocytosis but none of them had evidence of fungal infection
on CT scan.
5. We did not perform bronchoalveolar lavage
(BAL) after recovery as baseline information on BAL was not
available. We agree that GM antigen testing from BAL is more
sensitive as well as specific for invasive fungal infections.