Atul K. Sharma
H.K. Rangam
R.P. Choubey
From the Department of Gastrointestinal
Surgery, Surgical Division and Gastroenterology Center, Army
Hospital (Research and Referral), Rao Tularam Marg, Delhi 110
010, India.
Reprint requests: Lt. Col. Atul K. Sharma,
Gastrointestinal and Laparoscopic Surgeon, Surgical Division and
Gastroenterology Center, Army Hospital (Research and Referral),
Delhi Cantt 110 010, India.
E-mail: [email protected]
Manuscript received: April 5, 1999;
Initial review completed: May 5, 1999;
Revision accepted: October 7, 1999
Extra hepatic portal venous obstruction (EHPVO)
is the commonest cause of non-cirrhotic portal hypertension in
children and is usually found in patients from the lower
socio-economic strata(1). Management of these children who mainly
present with a massive upper gastrointestinal (GI) bleed, a big
spleen or hypersplenism, remains controversial, as sclerotherapy
or band ligation is difficult and pediatric endoscopes not readily
available. Also endoscopic therapy does not deal with hyper-splenism
and in the long term may lead to ectopic varices, which tend to
bleed torrentially and are usually not amenable to emergency
sclerotherapy or tamponade.
Fear of post-splenectomy infections on the
other hand deters most surgeons from per-forming a splenectomy and
there is only one large series from India which presents the
results of a side to side lieno renal shunt without splenectomy
for noncirrhotic portal hyper-tension in children(2,3).
We present our experience of and the outcome of
splenectomy and proximal Lieno-renal shunt in children with EHPVO.
All patients referred with non cirrhotic portal
hypertension to the Department of Gastro-intestinal Surgery were
evaluated by liver function tests, a hematological profile, an
ultrasound/Doppler scan of the splenoportal axis and an upper GI
endoscopy, to confirm the diagnosis of portal hypertension and
look for its etiology. The majority underwent a splenectomy and a
proximal end to side lieno-renal (Linton’s) shunt provided the
splenic vein was available (>4 mm in diameter) and the liver
function was not deranged. In either of the two instances above, i.e.,
if the splenic vein was found thrombosed, or the liver function
significantly deranged (Child’s B or C), a splenectomy and
gastro-esophageal devascularisation procedure was performed. A
wedge and needle biopsy of the liver was done only if there was
any gross evidence of nodularity at operation.
All patients were followed up calling them back
for review every 3 months for the first 6 months, and yearly
thereafter. The records of children (below the age of 14 years)
who underwent surgery from July 1992 to June 1998 have been
retrospectively analyzed to assess the outcome of our treatment
protocol.
During this period a total of 98 patients
underwent surgery for portal hypertension of which 32 were between
the age of 4 and 12 years (mean 6.2; SD 3.1). Twenty-two were boys
and 10 girls. The cause of portal hyper-tension was extrahepatic
portal venous obstruction in all except one 11-year-old girl who
had biliary cirrhosis due to Type IV (A) choledochal cyst. This
child was, therefore, excluded from the study. The indication for
surgery in the remaining 31 children was a GI bleed in 25 (80%);
of whom 10 (40%) had failure of sclerotherapy (recurrence of
bleeding despite two sessions of sclerotherapy). Three children
(10%) underwent emergent surgery as sclerotherapy failed to stop
the hemorrhage in the first instance. The mean number of bleeding
episodes before the children were referred for surgery was 3.2
(range 1-6; SD 2.4) and the mean number of blood transfusions
given to treat these bleeding episodes was 3.7 (range 1-5; SD
3.4). The remaining underwent surgery for hypersplenism (n = 4)
and/or a painful large spleen (n = 3). All 31 children underwent a
splenectomy (mean weight of spleen 1220 g; range 550 - 1580 g; SD
350.8). An end-to-side LR shunt was done in 27 with a mean shunt
diameter of 7.4 (range 4.5-10.5; SD 3.4) mm. In 4 the splenic vein
was thrombosed, thus gastroesophageal devascularization was
performed. Liver biopsy was not performed in any of these 31
children since in all, the liver was absolutely normal in
appearance and palpation, at the time of surgery.
There has been no operative mortality.
Twenty-five children (80%) have been followed up for a median
period of 3.7 (range 0.5-5.2) years with serial upper GI endoscopy
and ultrasound/Doppler scans. On followup the variceal grade was
always found to be two or less despite which 3 of the 24 shunts
followed up (12.5%) were reported to be blocked on Doppler
scanning. One child, after a devas-cularization procedure, had a
minor rebleed following administration of oral antipyretics. No
child ever developed encephalopathy.
Most Indian studies have highlighted EHPVO to
be the major cause of portal hypertension and the commonest cause
of major upper gastrointestinal bleeding in children(4,5). The
etiology of EHPVO in the majority is unknown, but the postulated
causes include congenital malformation of the portal vein or
acquired thrombosis following umbilical sepsis, intraluminal
trauma following exchange trans-fusion and pyelephlebitis
following intestinal infection. All these are commonly seen in
children from poorer sections of society. Most of these children
present with recurrent episodes of massive upper GI bleed, the
first usually occurring before the age of 10 years. Although
almost all these patients tolerate the bleeding episode well, some
children, especially below the age of 5, may develop transient
ascites soon after a bleed. Most have a moderate spleno-megaly,
although in some the spleen may reach the umbilicus. Some children
present with repeated epistaxis and on evaluation are found to
have hypersplenism. Liver function and histology is invariably
normal and the diagnosis easily made by a ultrasonographic
examination of the splenoportal axis, which in 90% of children
reveals a block at the formation of the portal vein. In the
remaining, either the entire splenoportal axis is thrombosed or
the block lies in the hilum of the spleen, giving rise to left
sided or "segmental" portal hypertension(1).
The treatment of an acute episode of
hematemesis is fairly standardized and consists of resuscitation
with blood and endoscopic sclerotherapy, which controls the
bleeding in 95%. These episodes are well tolerated in the
majority; however mortality rates upto 31% have been reported(6).
It is in the prevention of recurrence of such bleeds that
controversy exists and opinion is divided between endoscopic
management on one side and surgery with or without splenectomy on
the other.
We have managed these children by a uniform
protocol of splenectomy and proximal lieno-renal shunt in the
majority, performing a gastro-esophageal devascularisation
procedure only if the splenic vein was not available. After a
median follow up of 3.7 (±0.5-5.2) years, none of the patients
have rebled or developed encephalopathy or overwhelming post
splenectomy infection (OPSI). There has been no operative
mortality and the one time procedure has at the same time dealt
with the problem of hypersplenism. Our results compare well with
the largest series published from India from the All India
Institute of Medical Sciences, which is the premier center
routinely performing an end to side lieno-renal shunt for EHPVO in
children(7-9).
Compared to these results, a study from
Institute of Post Graduate Medical Education and Research,
Calcutta, has reported the outcome of sclerotherapy in 45
children. The number of sittings of sclerotherapy required for
obliteration of varices was 5.9±1.6. Retrosternal discomfort
(22%), dysphagia (22%), stricture (13%), esophageal ulceration
(13%) and fever (11%) were the complications reported. Although
variceal grade was reduced to 0-1 in 91%, rebleeding and
recurrences rate of 13% were noted on follow-up(10). A similar
study from SGPGI, Lucknow, has reported a much lower rebleed rate
after 8 sessions of sclerotherapy per child, but the follow up is
only for 19 months and the morbidity of the procedure has not been
detailed upon(11).
Endoscopic band ligation is a relatively new
procedure and may require fewer sittings and have a lower
incidence of complications and the attendant morbidity(12);
however, the procedure requires expertise and these patients need
to be followed up much longer to record the incidence of rebleed
from ectopic (fundal, duodenal and ileal varices).
Although there are various kinds of shunt
procedures with splenic preservation described, the only major
report from India is from PGIMER, Chandigarh, where routinely a
side to side lieno-renal (SSLR) shunt is performed and they have
not convincingly shown a reduction in the splenic size or dealt
with the problem of hypersplenism in their reports(2,3).
Protagonists of the endoscopic procedures and
SSLR shunt are keen on splenic pre-servation, but hypersplenism
with a bulky painful spleen in a child has its own morbidity
besides the chance of accidental rupture.
It is concluded that splenectomy and LR shunt
is a safe and effective one-time treatment for EHPVO, which deals
with both GI bleeds and hypersplenism.
Contributors:
All authors have operated on the patients (at least two in each
case). AKS is the guarantor of the manuscript. HKR and RPC have
helped in formatting the proforma and in data collection. They
have also critically reviewed the manuscript at each stage and
their suggestions have been incorporated in the final draft.
Funding: None.
Competing interests: None stated.
Key Messages |
-
Splenectomy and Lieno-Renal (LR) shunt is
a safe and effective one-time treatment for extrahepatic portal
venous obstruction in children which deals with both GI bleeds
and hypersplenism
-
Rebleeding even after shunt blockage is
rare.
- Considering the socio-economics of our country,
splenectomy and LR shunt is the prefered modality of treatment
for EHPVO.
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