Home            Past Issues            About IP            About IAP           Author Information            Subscription            Advertisement              Search  

   
correspondence

Indian Pediatr 2010;47: 813

Antisnake Venom in a Neonate with Snake bite


B Adhisivam,

Department of Pediatrics, JIPM, Education and Research (JIPMER), Pondicherry 605 006.
Email: [email protected] 
 


We read with interest the case report by Jindal, et al.(1) describing the management of a 27 day old neonate with snakebite envenomation. Surprisingly, there is no mention of ptosis in this case report of severe neurotoxic ophitoxemia. The dose of 50 vials (500 mL) of ASV used will neutralize 300mg of cobra venom and 225mg of krait venom which is well beyond the capability of each snake to achieve in a bite. This is a clear case of unnecessary overuse of ASV. The endpoint of ASV administration is where the dose is sufficient to neutralize any unbound venom. Keeping the reversal of respiratory and neuromuscular paralysis as the end point and pumping in ASV to achieve it as done in this case is definitely not rational. Twenty vials is the maximum that can be given to a patient with neurotoxic snakebite envenomation. Larger doses of ASV over prolonged duration have no benefit in reversing envenomation(2,3). ASV dose has nothing to do with body size but only the amount of venom injected. There is no good evidence to suggest children should receive either more ASV because of body mass or less in order to avoid adverse reactions(4). In summary, this case study can mislead peripheral doctors on the dose of ASV.

References

1. Jindal G, Mahajan V, Parmar VR. Antisnake venom in a neonate with snake bite. Indian Pediatr 2010; 47: 349-350.

2. Indian National Snakebite Protocols 2007. http://whoindia.org/LinkFiles/Chemical_Safety_ Snakebite_Protocols_2007.pdf

3. Mahadevan S, Jacobsen I. National snakebite management protocol, 2008. Indian J Emerg Pediatr 2009; 2 : 63-84.

4. Simpson ID. The pediatric management of snakebite the national protocol. Indian Pediatr 2007; 44: 173-176.
 

 

Copyright© 1999 by the Indian Pediatrics (Disclaimer)