1.gif (1892 bytes)                      

Case Reports

Indian Pediatrics 2008;45:775-777 

Persistent Pulmonary Interstitial Emphysema in a Preterm Infant

 

Ahmet Yagmur Bas*
Nurullah Okumus**
Nihal Demirel**
Aysegul Zenciroglu**

From the Neonatology Unit, Sanliurfa Obstetrics and Gynecology Hospital*, Sanliurfa, Turkey and **Department of Neonatology, Dr. Sami Ulus Children’s Hospital, Ankara, Turkey.

Correspondence to: Dr Ahmet Yagmur Bas, Sanliurfa Kadin Hastaliklari ve Dogumevi, Ipekyolu, Sanliurfa Turkey. E-mail: [email protected]

Manuscript received: August 14, 2007; Initial review completed: October 19, 2007;
Revision accepted: February 14, 2008.

Abstract

We report two premature infants who developed multiple brain abscesses following Klebsiella pneumoniae infection. Both the cases were diagnosed by ultrasonogram (USG) and cranial tomography. Abscess had intraventricular communication in one case. One infant was managed conservatively while the other required surgical drainage.

Key words: Brain abscess, Klebsiella pneumoniae, Neonates.

Pneumothorax, pneumomediastinum, and pulmo-nary interstitial emphysema (PIE) are the most common causes of air leak syndromes in the newborn period(1). Air escapes from intraalveolar space to interpleural area in pneumothorax and to mediastinal area in pneumomediastinum(1). In PIE, air accumulates in the interstitial tissues of the lung along the bronchovascular bundles and the interstitial septa leading to the formation of cysts(2).

Advanced use of mechanical ventilation and the increased survival of premature infants, has led to a rise in the incidence of PIE. Pulmonary interstitial emphysema may develop in preterm newborns treated with assisted ventilation such as nasal continuous positive airway pressure (CPAP). Air leaks, as well as pneumothorax do occur on CPAP, which may be related to overdistention of alveoli(2).

Case Report

A male infant was born to a 32 years old multigravida mother via spontaneous vaginal delivery at 33 weeks of gestation with a birthweight of 2440 grams. The Apgar scores were 7 and 8 at 1 and 5 minutes. Because of mild respiratory distress, nasal CPAP was instituted at 5 cm H2O (Hudson nasal prongs). The initial findings on chest radiography were compatible with mild respiratory distress syndrome (RDS). The child improved and required nasal CPAP only until his third day of life. The child was discharged at 7 days of age.

On 24th postnatal day, the infant was admitted to our children’s hospital with respiratory distress. Physical examination revealed tachypnea, intercostal retractions and mild cyanosis. Lung fields were clear, and there was no cardiac murmur. Initial laboratory studies, blood gases, complete blood count and C-reactive protein were normal. Chest X-ray showed paracardiac pulmonary densities and normal heart size and pulmonary vasculature.

Treatment was started with oxygen by hood (5 L/min) and ampicillin and gentamicin. The infant’s clinical status stabilized within 10 days, but retractions persisted. On hospital day 13, the infant’s retractions increased, and a chest film at this stage revealed diffuse cystic changes in the left lung (Fig. 1a), which was confirmed on CT (Fig. 1b). Repeated radiographs of chest revealed continued increase in left lung cystic lesions in the absence of further respiratory support. Given the diagnosis for localized persistent pulmonary interstitial emphysema (LPPIE), pediatric surgery unit offered left upper lobectomy. At this stage, we decided to manage the baby conservatively. Serial radiographs revealed slow resolution of LPPIE. The child recovered and was discharged on day 30 without tachypnea and retractions. There was no respiratory symptoms on follow-up after 1 and 2 month.

(a)

(b)

Fig.1(a) Diffuse cystic changes in the left lung. (b) Thoracic CT revealed multiple cysts of varying sizes occupying the entire of the left upper lobe, atelectasis in the left lower lobe and a mediastinal shift to the right.

Discussion

Pulmonary interstitial emphysema is a peribronchial, perialveolar air-leak syndrome, and can be classified clinically as acute (<7 days duration) or persistent(3). Persistent pulmonary interstitial emphysema (PPIE) is subclassified as localized or diffuse, according to the extent of involvement(4,5). Most cases of air leak syndromes occur in newborns with underlying lung disease, especially if mechanical ventilation is required(6).

In PIE, air enters the pulmonary interstitial tissue following rupture of an overdistended alveolus, and dissects along the periarterial sheath(7). Preterm infants are at increased risk because the perivascular connective tissue is more abundant and less dissectible in preterm than older infants. This predisposes to air trapping in the perivascular space resulting in pulmonary interstitiel emphysema (PIE)(1).

A number of adverse side effects and complications of CPAP have been described(8). It is not possible to conclusively identify that how CPAP led to the development of PIE in our infant. But it is claimed that air leaks, as well as pneumothorax do occur on CPAP. The mechanism may be related to overdistention of the more compliant areas of the lung(8). Localized PPIE may evolve from structural characteristics of the immature lung. This immaturity may explain the vulnerability to alveolar rupture of the preterm lung even in infants who are not mechanically ventilated, as in our case(9).

The differential diagnosis for cystic pulmonary changes includes congenital cystic adenomatoid malformation, lymphangiectasia, bronchogenic cysts, congenital lobar emphysema, cystic lymphangioma, diaphragmatic hernia and sequelae of prior infection(3). It is important to distinguish LPPIE from other cystic lesions because the initial management of LPPIE may be nonoperative.

There is little empirical data available to guide the management of infants suffering from LPPIE. In four of the previously reported LPPIE cases without history of mechanical ventilation, the infants underwent surgical lobectomy or pneumonec-tomy(3). We tried a conservative approach, maintaining spontaneous breathing by positioning the infant with the involved side down and, antibiotics and oxygen therapy.

Our case indicates that LPPIE may occur in preterm infants who have been treated with nasal CPAP and these cases can be successfully managed nonsurgically, if the diagnosis can be made by imaging prior to operative intervention.

Funding: None.

Competing interests: None stated.
 

 References


1. Madansky DL, Lawson EE, Chernick V, Taeusch HW Jr. Pneumothorax and other forms of pulmonary air leak in newborns. Am Rev Respir Dis 1979; 120: 729-737.

2. Stocker JT, Drake RM, Madewell JE. Cystic and congenital lung disease in the newborn. Perspect Pediatr Pathol 1978; 4: 93-154.

3. Stocker JT, Madewell JE. Persistent interstitial pulmonary emphysema: another complication of the respiratory distress syndrome. Pediatrics 1977; 59: 847-857.

4. Oh MH, Kim MY, Oh SS, Shin BK, Cho SJ, Kim HK. A case of localized persistent interstitial pulmonary emphysema. J Korean Med Sci 2001; 16: 225-228.

5. Cohen MC, Drut RM, Drut R. Solitary unilocular cyst of the lung with features of persistent interstitial pulmonary emphysema: report of four cases. Pediatr Dev Pathol 1999; 2: 531-536.

6. Yu VY, Wong PY, Bajuk B, Szymonowicz W. Pulmonary interstitial emphysema in infants less than 1000 g at birth. Aust Paediatr J 1986; 22: 189-192.

7. Yao JL, Fasano M, Morotti R, Caprio M, Greco MA. Demonstration of communication between alveolus and interstitium in persistent interstitial emphysema: case report. Pediatr Dev Pathol 1999; 2: 484-487.

8. Wiswell TE, Srinivasan P. Continuous positive airway pressure. In: Goldsmith JP, Karotkin EH (eds). Assisted ventilation of the neonate. 4th edn. Philadelphia: WB Saunders; 2003. p.127-147.

9. Bancalari E, Hodson A. Normal and abnormal structural development of the lung. In: Polin RA, Fox WW (eds). Fetal and neonatal physiology. 2nd ed. Philadelphia: WB Saunders; 1998. p.1033-1046.

Home

Past Issue

About IP

About IAP

Feedback

Links

 Author Info.

  Subscription