It is customary for the vaccinating agencies to use the multidose vials for vaccines like Hepatitis B and Hemophilus influenzae b. In this context, I seek a clarification as to how long can a single multidose vial be used after breaking open the seal. This, however, is subject to the assumption that the vials are being stored at adequate temperature and appropriate aseptic measures are being observed while repeatedly puncturing the rubber cap of the vials.

R.S. Malhotra,
Children Specialist,
168, Ajit Nagar,
Opp. Income Tax Office,
Patiala 147 001, India.

Reply

The multidose vials of vaccines are meant to be punctured the needed number of times to fully utilize the contents. If the multidose vial contains liquid vaccine, and if it is punctured under the usual careful handling, the vaccine can be used until the date of expiry given for that vial. Many vaccine maufacturers are now using better seals on their multidose vials, than the old fashioned latex seals. Thus, multidose vials of liquid vaccines are rather like multidose vials of insulin or antibiotics. If the multidose vial contains freeze dried vaccine, it should be used up withn 4 to 6 hours of reconstitution, and any left over doses must be discarded.

T. Jacob John,
Chairman, Committee on Immunization Indian Academy of Pediatrics,
2/91 Kamalakshipuram,
Vellore, TN 632 002, India.

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