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Indian Pediatr 2014;51: 221-222

7% Hypertonic Saline in Acute Bronchiolitis: A Randomized Controlled Trial

Source Citation: Jacobs JD, Foster M, Wan J, Pershad J. Pediatrics 2014;133:e8.

 


Summary

This randomized controlled trial compared 7% hypertonic saline versus 0.9% (normal) saline, in addition to racemic epinephrine (in both groups), among infants with mild to moderate severity bronchiolitis. The authors used a modification of the oft-applied bronchiolitis severity score (BSS) by Wang, et al. [1] to evaluate the efficacy of treatment at multiple time points until discharge/disposition from the hospital. They reported no statistically significant differences between the groups for changes in modified-BSS after 1 dose of treatment as well as until final disposition from the hospital.

Commentaries

Evidence-based-medicine Viewpoint

This study has the usual methodological refinements associated with a high-quality trial, including appropriate sequence generation, block randomization, allocation concealment and double-blinding (especially the outcome assessor). Although a convenience sample was enrolled, the number included was pre-calculated and adequately powered. The cohort of infants was consistent with the usual clinical understanding of bronchiolitis. Clinically relevant outcomes were chosen for evaluation of efficacy.

Some years back, Indian Pediatrics explored the issue of hypertonic saline as an adjunct therapy in bronchiolitis [2], and concluded that there was insufficient robust evidence to include it in routine practice. However, a Cochrane systematic review [3] published around the same time suggested a beneficial effect of hypertonic saline in terms of statistically significant reduction in clinical severity score and duration of hospital stay. At that time, all available studies had compared 3% hypertonic saline against normal saline. There is a single recent trial that used 5% hypertonic saline in some patients [4] but results are presented together with those receiving 3% saline. In that sense, this trial by Jacobs, et al. evaluating 7% hypertonic saline is the first of its kind. In fact, the authors have used this to justify their trial, expecting that 7% saline would be even more beneficial than 3% saline.

It is therefore surprising that Jacobs, et al. failed to mention the updated version of the Cochrane review published in May 2013 [5] that included a total of 11 trials. This review corroborated the previous version, again showing a statistically significant reduction in severity score and hospital stay. Strictly speaking, the trial by Jacobs, et al. may not be comparable to the trials included in the Cochrane review, as the intervention and the measurement tool for outcomes were different. However, the benefit of alluding to it would have been to report the findings using the same tools for outcome measurement as all the previous trials. This would have made it possible to incorporate Jacobs’ findings into the meta-analysis and assess its impact on the results available thus far.

This trial suggests that 7% hypertonic saline added to epinephrine may not provide additional benefit in bronchiolitis, although the balance of evidence is leaning towards adding 3% hypertonic saline to epinephrine for infants with bronchiolitis. The implications for research are two-fold viz that additional randomized trials may be required to resolve the issue and more important – new research should be conducted with an attempt to enrich existing knowledge, rather than for the sake of research itself.

Jospeh L Mathew
Department of Pediatrics,
PGIMER, Chandigarh, India.
Email: dr.joseph.l.mathew@gmail.com

Pediatric Pulmonologist’s Viewpoint

The debate on bronchiolitis and its management will remain a controversy for many years to come and the final word might be difficult to arrive at – with the present background. Bronchiolitis is defined as a clinical syndrome in children less than 2 years of age, characterized by upper respiratory tract symptoms followed by lower respiratory tract signs and symptoms – with no other explanation for the wheezing. However, the first episode of wheeze can be an overlap manifestation of episodic virus-induced wheezing or acute viral-triggered asthma. It is pertinent to remember that all first episodes of wheeze in young children within the agreed clinical definition are only "probable bronchiolits".

Inhaled epinephrine for bronchiolitis was found to be of benefit in the first day of care [6]. Nebulized 3% saline significantly reduces clinical severity score and also the length of hospital stay among children with non-severe acute bronchiolitis [5]. However a recent randomized control study in Indian context failed to elicit a favorable response [7]. In Indian children with cystic fibrosis, 3% hypertonic saline nebulization was better than 7% saline inhalation as a mucolytic [8].

A major hurdle in an interventional study is the difficulty to differentiate bronchiolitis from virus-induced wheeze or asthma, as each category responds differently making it difficult to determine the effect of each medication. Further, presence of two drugs – that could have a synergistic or antagonistic effect – makes the assessment of the effect of a single drug in such combination difficult. The present study is thought-provoking by being the first study with 7% saline. In clinical practice, 3% saline would remain the preferred choice when warranted. The use of 7% saline as a concept is interesting, but for now – is not promising.

So. Shivbalan
Consultant Pediatrician and Pulmonologist,
Sundaram Medical Foundation,
Dr Rangarajan Memorial Hospital,
Chennai, Tamil Nadu, India.
Email: sivabalan.somu@gmail.com

Practitioner’s Viewpoint

Given that bronchiolitis is one of those illnesses of infancy in which the treating physician is almost helpless and at his/her wit’s end – being unable to provide any definitive treatment to alleviate the symptoms – a new treatment modality is welcome. Over the past decades, proven effective treatments for bronchiolitis remain the same: oxygen and hydration. Routine use of corticosteroids or bronchodilators has no proven efficacy, although a trial of bronchodilators is worth a try. Evidence suggests that epinephrine may be more efficacious compared to salbutamol.

Nebulized hypertonic saline has shown promise as an alternative treatment option. The majority of studies are with 3% saline and some with 5% saline, either alone or in combination with epinephrine. The most recent Cochrane review [5] of this treatment modality suggests a definite advantage with reduced length of hospitalization in moderate to severe bronchiolitis and some improvement in clinical scores. No adverse effects with nebulized hypertonic saline have been reported. As far as 7% saline goes, this seems to be the first study to evaluate its efficacy in bronchiolitis: it does not show any additional benefit compared to nebulization with normal saline and epinephrine. Nebulized 7% saline has also not shown any additional benefit in patients with cystic fibrosis [9]. For infants hospitalized with bronchiolitis, the most justifiable and safe treatment option (apart from supportive treatment with oxygen and intravenous fluids) may be a trial of nebulized epinephrine with 3% saline that is to be continued if a definite objective improvement is demonstrated.

Vineet Sehgal
Consultant Pediatrician,
Max Healthcare, New Delhi, India.
Email: vinnetdoc@hotmail.com

References

1. Wang EE, Milner RA, Navas L, Maj H. Observer agreement for respiratory signs and oximetry in infants hospitalized with lower respiratory infections. Am Rev Respir Dis 1992;145:106-9.

2. Mathew JL. Hypertonic saline nebulization for bronchiolitis. Indian Pediatr 2008;45:987-9.

3. Zhang L, Mendoza-Sassi RA, Wainwright C, Klassen TP. Nebulized hypertonic saline solution for acute bronchiolitis in infants. Cochrane Database Syst Rev 2008; 4:CD006458.

4. Al-Ansari K, Sakran M, Davidson BL, El Sayyed R, Mahjoub H, Ibrahim K. Nebulized 5% or 3% hypertonic or 0.9% saline for treating acute bronchiolitis in infants. J Pediatr. 2010;157:630-4.

5. Zhang L, Mendoza-Sassi RA, Wainwright C, Klassen TP. Nebulised hypertonic saline solution for acute bronchiolitis in infants. Cochrane Database Syst Rev 2013;7: CD006458.

6. Hartling L, Bialy LM, Vandermeer B, Tjosvold L, Johnson DW, Plint AC, et al. Epinephrine for bronchiolitis. Cochrane Database Syst Rev. 2011;6:CD003123.

7. Sharma BS, Gupta MK, Rafik SP. Hypertonic (3%) saline for acute viral bronchiolitis: A randomized trial. Indian Pediatr. 2013;50:743-7.

8. Gupta S, Ahmed F, Lodha R, Gupta YK, Kabra SK. Comparison of effects of 3 and 7% hypertonic saline nebulization on lung function in children with cystic fibrosis: a double-blind randomized, controlled trial. J Trop Pediatr. 2012;58:375-81.

9. Rosenfeld M, Ratjen F, Brumback L, Daniel S, Rowbotham R, McNamara S, et al.; ISIS Study Group. Inhaled hypertonic saline in infants and children younger than 6 years with cystic fibrosis: the ISIS randomized controlled trial. JAMA. 2012;307:2269-77.

 

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