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correspondence

Indian Pediatr 2011;48: 249

Re-evaluation of Congenital Hypothyroidism


P Ramesh Menon and K Rajmohan

Department of Pediatrics, Government TD Medical College, Alappuzha, Kerala, India.
Email: [email protected]
 
 


I read with much interest the work done by Nair, et al. [1] in evaluating children with congenital hypothyroidism and the effect of stopping/withholding thyroxine by 3 years of age. I would like to highlight that with a smaller sample and non-normal distribution of data, reporting of medians may be more relevant, as in the case of age at diagnosis. In addition, since repeated measurements of TSH, T4 and T3 were available, repeated measures analysis of variance (RMANOVA), would have been a more appropriate test to be used. If the assumption of fixed interval between repeated measures is violated or differences are non-normal, Friedman test may be applied. The conclusions drawn that permanent and transient hypothyroidism had significantly different TSH values to begin with and different dosing requirements of thyroxine may still be valid and biologically plausible.

Reference

1. Nair PS, Sobhakumar S, Kailas L. Diagnostic re-evaluation of children with congenital hypothyroidism. Indian Pediatr. 2010;47:757-60.
 

 

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