1.gif (1892 bytes)

Letters to the Editor

Indian Pediatrics 2005; 42:294-295

Neonatal Hypocalcemia Due to Asymptomatic Maternal Primary Hyperparathyroidism


Neonatal hypocalcemia resulting from maternal primary hyperparathyroidism (MPH) is usually detected clinically in the first 2 weeks of life. Occasionally, diagnosis of primary hyperparathyroidism in a young asymptomatic mother is made when the infant presents with hypocalcemia. We present an infant with late onset hypocalcemia resulting from a combination of transient hypo-parathyroidism due to asymptomatic MPH and vitamin D deficiency.

A thirty-five-day-old infant was admitted to Pediatric Emergency Service because of recurrent tonic-clonic convulsions for 36 hours. He was a full term male baby born to a 22 year old G2, P2 woman by normal spontaneous vaginal delivery with a birth weight of 3500 g. He was only breast fed. The family history revealed that his brother was hospitalized and treated because of neonatal hypocalcemic convulsion but no further investigations were carried out.

Table  I
Laboratory Data and Treatment Details.	
  Normal
ranges
 
Patient
at admission
 
Follow up
2nd day
 
5th day
 
10th day
 
2nd wk 5th wk 16th wk Mother
Ca(mg/dL)
8.5 -10.5
4.6
7.4
8.2
8.6
8.8
9
8.9
11.2
P(mg/dL)
 2.7 - 6.7
8.6
5.9
5.1
4.7
4.7
4.2
4.1
2.2
ALP(IU/l)
60 - 250
438
437
464
464
460
420
519
Mg(mg/dL)
1.2 - 2.5
1.7
1.7
1.8
1.0
PTH(pg/mL)
15 - 65
19
32
64.1
1402
25 OH VD3 
(ng/mL)
10 - 40
5
35
Treatment                     Ca IV

 
Ca IV+PO
D3(800
IU/d)
Ca IV+PO
D3 (800)
IU/d)
D3
(800
IU/d)
D3
(800
IU/d)
D
(800
IU/d)
D3
(800
IU/d)
Surgery*

 

*Parathyroid adenoma was removed.

On physical examination his anthro-pometric measurements were normal. He had no dysmorphic features. Initial laboratory evaluation showed hypocalcemia, hyper-phosphatemia slightly increased alkaline phosphatase (ALP), inappropriately low PTH level for concurrent degree of hypocalcemia and sligthly low 25-OH vitamin D3 (Table I). The remainder of the laboratory findings were unremarkable. Based on these findings, he was diagnosed as hypoparathyroidism and started on calcium boluses. After his calcium level reached 7mg /dL, oral calcium (75 mg/g/day) and vitamin D3 supplements (800 IU/day) were given. He remained asymptomatic after second day on admission. Since he had no findings consistent with DiGeorge syndrome and he had a positive family history, maternal hyperparathyroidism was investigated. The mother had high levels of calcium and PTH and low level of phosphorus. She was diag-nosed as hyperparathyroidism and referred to endocrinologist. A technetium scan showed an area of increased uptake on the right side of neck suggesting a parathyroid adenoma. It was removed by surgery.

The presentation of asymptomatic maternal hyperparathyroidism by convulsion in an infant is exceedingly rare. Hyper-parathyroidism in asymptomatic mothers might easily have been missed if the maternal calcium status had not been investigated(1-4) like in our patient’s mother. Suppression of the fetal parathyroid gland by maternal hypercalcemia often causes transient neonatal hypocalcemia(5). Low vitamin D levels of the patient might have exacerbated the hypocalcemia observed in this infant which may due to several causes : he has not received vitamin D supplement , he has grown rapidly and there could have been low placental transfer of 25-OH D3 from the mother who had increased conversion of 25-OH D3 to 1,25-OH D3 due to her hyperparathyroidism. We emphasize that all mothers with neonates showing tetany or hypocalcemic convulsions should have serum calcium concentrations measured to exclude primary hyper- parathyroidism even if the mother is asymptomatic.

Filiz Tutunculer,
Hulya Gunoz,

Istanbul University,
Istanbul Faculty of Medicine,
Department of Pediatrics,
Growth-Development and Pediatric Endocrinology Unit,
Istanbul, Turkey.
E-mail: [email protected]
 

References

1. Beatti GC, Ravi NR, Lewis M, Williams H, Blair AW, Campbell IW, et al. Rare presentation of maternal primary hyperparathyroidism. Br Med J 2000; 321: 223-224.

2. Brisse F, Breton D, Gagey V, Cheron G. Convulsion and neonatal hypoparathyrodism maternal hyperparathyroidism. Pediatrics. 1994; 1: 255-259.

3. Cemeroglu AP, Böber E, Büyükgebiz A. Prolonged hypocalcemia in a 2-month-old boy unmasking maternal diagnosis of primary hyperparathyroidism. J Pediatr Endocrinol Metab 2001; 14: 785-787.

4. Hanukoglu A, Chalew S, Kowarski A. Late onset hypocalcemia, rickets and hypo-parathyroidism in an infant of a mother with hyperparathyroidism. J Pediatr 1988; 112: 751-754.

5. Aurbach GD, Marks SJ, Spiegel AM. Parathyroid Hormone, Calcitonin and the Calciferols. In: Wilson JD, Foster DW. eds. Williams’s Textbook of Endocrinology. Phiadelphia: WB Saunders. 1985; pp.1137-1217.

Home

Past Issue

About IP

About IAP

Feedback

Links

 Author Info.

  Subscription