Dr. Anandkesavan has noted some side effects associated with nimesulide therapy which were not observed by us. Our study in­cluded hundred patients only and with more widespread use some side effects which are not common or hitherto not described may surface. However, gross hematuria observed by him has been ascribed to renal toxicity without details of urinary examination. Nimesulide is known to have some adverse effect on platelet functions but its direct involvement in hemorrhagic complications is not clinically substantiated(1,2). Similarly the exact. mechanism of periorbital edema is not clear. One more important aspect is that most of the liquid preparations of nimesulide have 50 mg of the drug in each 5 ml. With a dose of 1.5 mg/kg, a very small volume is required to be administered particularly for young chil­dren. Over dosage should be looked into in cases exhibiting rare side effects.

                                                       Jagdish Chandra
  Professor of Pediatrics,
Kalawati Saran Children' s Hospital,
Lady Hardinge Medical College,
New Delhi 110001, 1ndia.