We report four cases of kwashiorkar in infants, who had a pre
existing skin disorder and who were on dietary restrictions as part of
their treatment in Alternative medicine.
Complementary and alternative medicine are increasingly
being used to diagnose or treat allergic diseases, and numerous studies
have reported benefits of this type of medicine. However, severe
nutritional deficiencies can occur in infants and small children given
strict alternative diets, leading to ‘kwashiorkor’(1). These four cases,
three of whom had atopic dermatitis and one had epidermolysis bullosa,
presented with generalized edema, skin peeling, hair changes, apathy, and
not gaining weight. On examination, three of these cases had kwashiorkar
and one had marasmic kwashiorkor. Investigations supported the diagnosis.
In all these cases, the nutritional deficiencies were caused by severe
dietary restriction placed by the treating alternative medicine. The ratio
of protein to energy in this diet is very low as most forms of protein are
taboo in this diet(1). For example, cow’s milk and milk products except
ghee, pulses and oils as they are "gas forming", Ragi and most fruits as
they are "cold food", were restricted. It is this imbalance in the dietary
ratio of protein to energy that has been implicated in the pathogenesis of
kwashiorkor(2). The families involved do not fit the stereotypic profile
in which malnutrition would be anticipated. The parents were
well-educated, seemed knowledgeable and responsible, and had at least
average family income. Diagnoses were delayed by a low index of suspicion
as the skin changes of kwashiorkar were thought to be an exacerbation of
the primary skin problem. In addition, kwashiorkar is uncommon in Kerala,
and as a result, physicians may be unfamiliar with their clinical
features. With resumption of a proper diet, the edema subsided in two
weeks and skin changes were reversed, though the primary skin lesions
persisted.
We were unable to find previous reports of kwashiorkor
caused by dietary restriction as a part of treatment in alternative
medicine, but cases may have occurred and may have not been reported. A
heightened level of vigilance is required so that nutritional deficiency,
which may result in severe life-threatening complications, is not
overlooked.
Acknowledgment
We gratefully acknowledge the help and guidance given
by Dr V K Parvathy, Head and Professor of Pediatrics and Dr S Criton, Head
and Professor of Dermatology, Amala Institute of Medical Sciences,
Thrissur, Kerala.
References
1. Niggemann B, Gruber C. Side-effects of
complementary and alternative medicine. Rev Allergy 2003; 58: 707-716.
2. Rossouw JE. Kwashiorkor in North America. Am J Clin Nutr 1989; 49:
588-592.