A 13-year old girl was bitten by a dog two years ago, grade II bite on
right leg. The same dog had also bitten 3 cattle and 2 other persons,
subsequently the dog was killed. All the 3 cattle died and 2 other persons
received post-exposure prophylaxis and did not have any problems
afterwards. However, our patient did not receive any post-exposure
prophylaxis and there was no history of receiving rabies vaccine any time
in past. The patient was admitted in the Pediatrics ward of our hospital,
2 years after the bite, with the complaints of bodyache, inability to
drink and hydrophobia. The patient was a febrile and had stable
cardiopulmonary status. She was also experiencing pain in the healed scar
at the site of bite. The patient was anxious and apprehensive but alert,
with tone and power of muscle being normal, the deep tendon reflexes were
brisk. There was no evidence of cranial nerve palsy, focal neurological
deficit or signs of meningeal irritation.
There is no specific treatment available for rabies and
supportive treatment may prolong survival up to 133 days [1]. Survival
from rabies is rare, there are six cases of rabies survival reported in
literature [2]. The pathognomonic sign of rabies is hydrophobia. Clinical
reports included the hypothesis that death resulted from neuro-transmitter
imbalance and autonomic failure, supportive care was predicted to succeed
[3].
Our patient became symptomatic after an unusual long
incubation of 2 years. Nicholas, et al. reported a case of rabies
with an incubation period of more than 6.5 years [4]. The Milwaukee
protocol has been used in treatment of acute infection of rabies in human
beings, the treatment involves putting the patient in to a chemically
induced coma and administering antiviral drugs [3]. However, our patient
recovered with supportive treatment only, without any residual deficit.
The patient was diagnosed rabies clinically on the basis of hydrophobia
and confirmed by demonstration of Rabies Antibodies in serum (EIA-1.6 IU/mL).
References
1. Gode GR, Raju AV, Jayalakshmi TS, Kaul HL, Bhide NK.
Intensive care in rabies Therapy: clinical observations. Lancet.
1976;2:6-8.
2. Emmons RW, Leonard LL, DeGenaro F Jr, Protas ES,
Bazeley PL, Giammona ST, et al. A case of human rabies with
prolonged survival. Intervirology. 1973;1:60-72.
3. Willoughby RE, Tieves KS, Hoffman GM, Ghanayem NS,
Amlie-Lefond CM, Schwabe MJ. Survival after treatment of rabies with
induction of coma. NEJM. 2005: 352:2508-14.
4. Nicholas J, Antomy F, Kenneth M. Re-examination of
human rabies case with long incubation, Australia. Emerg Infect Dis.
2008;352:2508-14.