To determine vitamin D requirements, dose response
studies with various doses are essential. There is very little data on
dose response to vitamin D in the Indian context. However, several
studies have reported that if vitamin D is given together with calcium,
and the compliance is adhered to, there is a significant increase in
vitamin D concentrations [1].
The action of vitamin D on bone is mainly through the
absorption of calcium. One of the major problems in the Indian children
is poor intake of calcium and low calcium-to-phosphorous ratio. As this
is very specific to Indian circumstances, the guidelines have stressed
that adequate intake of calcium at all age groups is critical. We have
considered data pertinent to the Indian situation while drafting the
guidelines. Another set of recent Global guidelines specifically meant
for children has Indian representation, and they also considered Indian
data [2].
While many reasons have been suggested for low
vitamin D concentrations in Indians, lack of exposure to sunlight (the
main source of vitamin D in Indians) is likely to be a major
contributor. Thus, for the prevention of vitamin D deficiency in
Indians, the ICMR report on recommended daily intake (RDI) for Indians
states that increasing the RDI for vitamin D is not the solution but
ensuring adequate exposure to sunlight is. Therefore, the ICMR Committee
agreed outdoor physical activity as a mean to achieve adequate vitamin
D. This is reflected in their recommendations and they make no specific
suggestions for vitamin D intakes in different groups [3]. However,
under situations of minimal sunlight exposure, a specific recommendation
of a daily supplement of 400 IU (10 µg) has been suggested.
In references quoted by authors of this
correspondence around 95% subjects were vitamin D deficient; hence,
doses to prevent vitamin D deficiency would be insufficient. However,
other Indian studies have shown a good response to 600 IU vitamin D
supplementation per day with little difference between 600 and 1000 IU
doses [4,5].
Acknowledgements: Dr Pramod Jog, Past President
Indian Academy of Pediatrics (2016), Dr Jagdish Chinnappa, Dr Narendra
Rathi, Dr Rajesh Khadgawat and Dr Balasubramanian provided their expert
comments for preparing this manuscript.
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