Asthma and Diet: Could Food be thy Medicine?

Editorial

Indian Pediatr 2015;52: 21-22

	Asthma and Diet: Could Food be thy Medicine?
Lokesh Guglani and #Christine Lm Joseph From the Pediatric Pulmonary Division, Department of Pediatrics, Children's Hospital of Michigan and Wayne State University School of Medicine; and #Department of Public Health Sciences, Henry Ford Health System; Detroit MI, USA. Email: [email protected]
The rising prevalence of asthma in the developed world has focused the attention of researchers on changes in the host and the host's immediate environment [1]. In the later part of the twentieth century, the emphasis was on the role of infections, and the ‘hygiene hypothesis’ [2] was proffered as an explanation for the underlying immune dysfunction associated with asthma and allergic disorders. This hypothesis, however, cannot explain the disproportionate prevalence of asthma in certain populations or ethnic groups [3], leading to the exploration of genetic factors that could modulate the risk for the development of asthma and allergic disorders [4]. The first decade of 21st century saw a great deal of work on establishing the genetic basis using genome-wide association studies [5] and whole genome sequencing [6]. Genetic studies also helped to identify susceptibility genes as well as the mediators (such as IL-33 and IL-25) that were involved in the pathogenesis of allergic inflammation [7]. The recognition of some of these mediators that influence gut immune responses led to the exploration of the role of various food items and how they change the gut’s immune profile [8]. Several studies have looked at specific nutrients (such as Vitamin D) [9] as well as diet patterns [10] on the risk and severity of asthma, and the results have been mixed. Another offshoot of this emphasis on the impact of certain foods or diets is the study of the changes in the gut's microbial profile (or ‘microbiome’) [11]. This microbiome varies between individuals and can be influenced by a combination of early life exposures such as infections or infestations, genetic factors and exposure to various macro- and micronutrients in the developing gut (either in utero or in early infancy). Alterations in the gut microbial profile influence the immune response that modulates the inflammatory mediators and skews the pathways of inflammation towards an allergic phenotype [12]. The article by Silviera, et al. [13] in this issue of Indian Pediatrics assesses the influence that dietary patterns may have on asthma severity. The study was conducted in two outpatient clinics in Brazil where 394 children between the ages of 3 to 12 years with either intermittent or persistent asthma were enrolled over a period of one year. Dietary patterns were assessed by parental recall of intake of specific foods >3 times/week or £3 times/week. The cases of persistent asthma were compared to those with intermittent asthma using multivariate logistic regression after controlling for the various confounding factors. The authors did not find any significant associations between dietary patterns and asthma severity, but did note that obesity was a significant risk factor for persistent asthma. This is not surprising given that multiple studies have established how obesity skews the immune response towards the Th2 phenotype [14]. However, obesity may also develop as a consequence of ‘westernized’ dietary patterns that consist of greater amounts of processed foods and hence the role of diet could still be an indirect one. Their study was not adequately powered to detect a difference in asthma severity and there is the potential for parental recall bias in responding to questions about food consumption patterns for their children. Other findings from this study included a significant association of asthma severity with maternal smoking during pregnancy and with premature birth. These are established risk factors that have been shown to be important determinants of asthma severity in other studies [15]. Modulation of diet has been shown to affect a number of chronic illnesses in adults such as diabetes [16], heart disease [17] and cancer [18], but the evidence for asthma is lacking. A recent meta-analysis of all the published studies related to diet patterns from various countries failed to show a relationship between diet patterns and asthma outcomes [19]. However, the authors did note that for studies involving children, the Mediterranean diet did have a protective effect on current wheezing and lifetime diagnosis of asthma. The authors included 31 studies from their systematic review of the literature, but included only adult studies for the meta-analysis. There were significant differences among the included studies regarding the definition of Mediterranean diet and what food groups were included during data collection. In addition, the food intake patterns are also influenced significantly by local food availability and cultural practices. Therefore, a prospective (preferably randomized controlled) study design with larger sample size and an in-depth collection of food consumption data stratified by different categories of asthma severity should be done to further explore the impact of various foods on severity, clinical course and outcomes of chronic diseases such as asthma. Only then will there be some definitive evidence to support this controversial [20] quote from Hippocrates: "Let food be thy medicine, and medicine be thy food." References 1. Akinbami LJ, Moorman JE, Garbe PL, Sondik EJ. Status of childhood asthma in the United States, 1980-2007. Pediatrics. 2009;123(Suppl 3):S131-45. 2. Strachan DP. Hay fever, hygiene, and household size. BMJ. 1989;299:1259-60. 3. Douwes J, Pearce N. Commentary: The end of the hygiene hypothesis? Int J Epidemiol. 2008;37:570-2. 4. Cookson WO, Moffatt MF. Genetics of asthma and allergic disease. Hum Mol Genet. 2000;9:2359-64. 5. Garcia-Sanchez A, Isidoro-Garcia M, Garcia-Solaesa V, Sanz C, Hernandez-Hernandez L, Padron-Morales J, et al. Genome-wide association studies (GWAS) and their importance in asthma. Allergol Immunopathol (Madr). 2014 Nov 26:doi: 10.1016/j.aller.2014.07.004. [Epub ahead of print] 6. Campbell CD, Mohajeri K, Malig M, Hormozdiari F, Nelson B, Du G, et al. Whole-genome sequencing of individuals from a founder population identifies candidate genes for asthma. PLoS One. 2014;9:e104396. 7. Moffatt MF, Gut IG, Demenais F, Strachan DP, Bouzigon E, Heath S, et al. A large-scale, consortium-based genomewide association study of asthma. NEJM. 2010;363:1211-21. 8. Kau AL, Ahern PP, Griffin NW, Goodman AL, Gordon JI. Human nutrition, the gut microbiome and the immune system. Nature. 2011;474:327-36. 9. Mirzakhani H, Al-Garawi A, Weiss ST, Litonjua AA. Vitamin D and the development of allergic disease: How important is it? Clin Exp Allergy. 2014; Oct 13: doi: 10.1111/cea.12430. [Epub ahead of print] 10. Garcia-Marcos L, Canflanca IM, Garrido JB, Varela AL, Garcia-Hernandez G, Guillen Grima F, et al. Relationship of asthma and rhinoconjunctivitis with obesity, exercise and Mediterranean diet in Spanish schoolchildren. Thorax. 2007;62:503-8. 11. Ly NP, Litonjua A, Gold DR, Celedon JC. Gut microbiota, probiotics, and vitamin D: Interrelated exposures influencing allergy, asthma, and obesity? J Allergy Clin Immunol. 2011;127:1087-94. 12. Azad MB, Kozyrskyj AL. Perinatal programming of asthma: The role of gut microbiota. Clin Dev Immunol. 2012;2012:932072. 13. Silveira DH, Zhang L, Prietsch SOM, Vecchi AA, Susin LRO. Association between dietary habits and asthma severity in children. Indian Pediatr. 2015;52:25-30. 14. Frey U, Latzin P, Usemann J, Maccora J, Zumsteg U, Kriemler S. Asthma and obesity in children: Current evidence and potential systems biology approaches. Allergy. 2015;70:26-40. 15. Kelly YJ, Brabin BJ, Milligan P, Heaf DP, Reid J, Pearson MG. Maternal asthma, premature birth, and the risk of respiratory morbidity in schoolchildren in Merseyside. Thorax. 1995;50:525-30. 16. Huo R, Du T, Xu Y, Xu W, Chen X, Sun K, et al. Effects of Mediterranean-style diet on glycemic control, weight loss and cardiovascular risk factors among type 2 diabetes individuals: a meta-analysis. Eur J Clin Nutr. 2014;Nov 5: doi: 10.1038/ejcn.2014.243. [Epub ahead of print] 17. Widmer RJ, Flammer AJ, Lerman LO, Lerman A. "The Mediterranean Diet, its Components, and Cardiovascular Disease". Am J Med. 2014;Oct 15: doi: 10.1016/j.amjmed.2014.10.014. [Epub ahead of print] 18. Wang Q, Hao J, Guan Q, Yuan W. The Mediterranean diet and gastrointestinal cancers risk. Recent Pat Food Nutr Agric. 2014 Oct 24. [Epub ahead of print] 19 Lv N, Xiao L, Ma J. Dietary pattern and asthma: A systematic review and meta-analysis. J Asthma Allergy. 2014;7:105-21. 20. Cardenas D. Let not thy food be confused with thy medicine: The Hippocratic misquotation. ESPEN J. 2013;8:e260-2.