Scorpion envenomation by Indian
red scorpion, Mesobuthus tamulus is frequently seen in rural
areas of Central India with significant mortality. Pediatric population
accounts for nearly 28% of victims [1]. There are no exclusive studies
on anti-scorpion venom (AScV) in pediatric patients. Moreover many
published studies excluded victims with life threatening manifestations
like pulmonary edema and shock and thus evidence for the role of
antiscorpion venom in these conditions is limited. This study was
conducted with the aim of analyzing the influence of AScV when used
along with Prazocin on entire clinical spectrum of morbidity and
mortality in children affected by scorpion envenomation.
Methods
This was a prospective case control study conducted
in the Department of Pediatrics, SS Medical College and associated GM
Hospital, Rewa, Madhya Pradesh from May 2011 to November 2011. Sixty two
patients (age 1 to 18 years) with history of scorpion sting were
enrolled in the study. Clinical Composite Scoring system (CCS) by Natu,
et al. [1] was used for assessment of severity of symptoms and
calculation of AScV dose. The maximum CCS that could be attained was 25
and the minimum was zero. Patients with CCS 5-25 were included in the
study and informed consents were taken. Those with CCS of <5 at the time
of admission were excluded even if they deteriorated later. Prazosin was
given in a dose of 30 micrograms per kg body weight to all patients on
admission and three hourly till symptoms abated.
Anti-scorpion venom is available as a lyophilized,
monovalent refined immunoglobulins and is manufactured by Haffkine
bio-pharmaceutical corporation Ltd, Pune. Doses of AScV were determined
by CCS and age of patients. AScV was administered only after a test dose
(0.1 mL SC) and no adverse reaction to the anti-venom was noticed. No
absolute contraindication was mentioned by the manufacturer. A vial of
AScV was dissolved in 10 ml distilled water and injected IV over a
period of 5-7 minutes. Procedures for procurement of anti-venom was
started in May 2011 and it was available from August 2011.
The study was started from May 2011 and patients
admitted till 31 July received only Prazocin, as anti venom was
unavailable and were termed as group A (Prazocin only group). All
patients with CCS more than 5 and admitted after the procurement of anti
venom received both AScV and Prazocin, and were labeled as group B (Prazocin
+ AScV group).
Heart rate and respiratory rate were recorded from
multipara monitor at 0, 6, 24 and 48 hours. Monitoring of blood
pressure, capillary refilling time, peripheral temperature and chest
auscultation for crepitations were also done at frequent intervals.
Clinical recovery was assessed based on a set of uniform parameters
like, normal heart rate, respiratory rate and blood pressure for age and
sex of the patients and presence of normal neurological status. The
average duration of hospital stay in two groups was also calculated.
Shock was identified on the basis of following clinical features; feeble
peripheral pulses, oliguira, altered mental status and less than normal
values of blood pressure for age and sex. Ionotropic support was started
with Dobutamine 5 mcg and titrated up to maximum of 15 mcg per kg of
body weight. Dopamine was added to cases not showing satisfactory
response with dobutamine monotherapy.
Results
Thirty five children (56.45%) received only prazocin
and were labeled as Group A. Twenty seven children (43.5%) received both
prazocin and anti-scorpion venom and they were labeled as Group B.
Baseline demographic and clinical factors including CCS were comparable
in two groups (Table I).
TABLE I Baseline Characteristics of the Patients at the Time of Admission
|
Group A
|
Group B
|
Total
|
|
(n= 35) |
(n = 27) |
(n=62)
|
Age (y) |
6.2 (3.8) |
4.9 (3.5) |
5.6 (3.7 ) |
M:F |
3:2 |
3:1 |
2:1
|
*Pulmonary edema
|
9 (25.7%) |
5 (18.5%) |
14 (22.6%)
|
Heart rate
|
129 (27) |
131.6 ( 28) |
130.1 (27)
|
Respiratory rate |
40.9 (13.4) |
41.3 (8.5) |
41.1 (11.4)
|
Systolic BP |
93.0 (22.5) |
97.1 (26.0) |
94.8 (24.0)
|
Diastolic BP |
49.0 (27.6) |
55.9 (22.8) |
52.0 (25.6)
|
CCS |
10.9 (3.0) |
10.8 (2.8) |
10.8 (2.9 ) |
BP-blood pressure; All values in mean
(SD); * values in no. (%); ccs-composite clinical score. |
Requirement for inotropic support with dopamine and
dobutamine and the average duration of inotropic support with dobutamine
were significantly less in group B compared to group A (P<0.05).
Duration of dobutamine therapy was also significantly longer in group A
than group B. Requirement of inotropic support with dopamine also showed
similar trend, and the difference was statistically significant (Table
II). Duration of dopamine therapy and requirement and duration of
nitroglycerine were not significantly associated with AScV therapy.
TABLE II Clinical Profile of Two Groups
|
Group A
|
Group B |
P |
|
(n= 35) |
(n=27) |
value |
Dobutamine N (%) |
28 (80.0%) |
16 (59.3%) |
0.074 |
Duration, mean (SD) |
31.4 (22.8) |
17.5 (17.0) |
0.040 |
Dopamine N (%) |
17 (48.6%) |
5 (18.5%) |
0.014 |
Duration, mean (SD) |
22.71 (16.3) |
28.4 (26.8) |
0.56 |
Early
discharge (<48 hours) |
2 (6.7%) |
9 (36.0%) |
0.007 |
Hospitalization mean (SD), h |
74.89 (52.01) |
59.24 (24.74) |
0.155 |
Death
|
5 (14.3%) |
2 (7.4%) |
0.657 |
There was no statistically significant difference in
duration of hospital stay between two groups. Mortality was lesser in
group B (7.4%) than in group A (14.3%), but the difference was not
statistically significant (Table II). Duration of hospital
stay depended on time elapsed between sting and anti-venom
administration. Average duration of hospital stay in children who
received anti-venom within six hours was 53.9 hours compared to 67.0
hours in those received AScV after six hours, and the difference was
statistically significant.
Discussion
Scorpion anti-venom is effective in neutralizing the
venom present in the circulation and other body compartments. Prazocin
treatment is directed toward neutralizing the effects of the
over-stimulated autonomic nervous system [1]. Demographic and baseline
data of both the groups were comparable and children who received
anti-scorpion venom documented an earlier clinical recovery and lesser
systemic complication like shock, than those with same CCS scoring but
received no AScV. This indicates the effectiveness of anti-scorpion
venom in reverting the adverse effect of circulating venom.
The delay in initiation of treatment had a poor
prognostic effect in the outcome as those children who received AScV
within 6 hours of sting showed better outcome than late receivers.
Bawaskar and Bawaskar also reported similar benefits of early
administration of AScV [4].
Myocarditis and cardiogenic shock are the life
threatening complication of the envenomation. Cardioprotective effect of
antivenom is evident from the fact that requirement and duration of
ionotropic support were significantly lesser in group B (AScV + Prazocin)
than group A (Prazocin only).
There were no anaphylaxis or allergic reactions
reported during the study .This adds to the acceptance of AScV in
children. Similar safety profile was reported previously by Natu, et
al. [1]. Higher mortality rates in our study than previous reports
[2,3] could be due to the inclusion of patients with life threatening
complications like shock with CCS >15, while most of the studies
excluded critically ill patients with CCS 15 and more.
Limitations of the study were lack of randomization,
and use of CCS, which is not well validated in younger children.
Evidence regarding effectiveness of anti-scorpion
venom in children with systemic signs of envenomation has been found in
this study. Previous studies had conflicting reports about anti-scorpion
venom [4,5], but our study proved that AScV when used along with
prazocin is safe in children and useful in hastening clinical recovery,
preventing worsening of clinical condition, and reducing the requirement
and duration of cardiorespiratory support.