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Correspondence

Indian Pediatr 2017;54: 1057

Comparative Efficacy and Safety of Caffeine and Aminophylline for Apnea of Prematurity: Few Concerns: Author's Reply

 

M Shivakumar and *Leslie Edward Simon Lewis

Department of Pediatrics, Women and Child block, Kasturba Medical College, Manipal, India.
Email: [email protected]

 

   


We are thankful to readers for keen interest in our study [1].

There were a couple of typographical errors in the published paper. We regret these typographical errors and thank the readers for pointing them out. We have already submitted an erratum that has been published in the October 2017 issue of the journal on page 870.

Apnea is categorized based on presence or absence of upper airway obstruction; 40% of the episodes are central or diaphragmatic with no evidence of obstruction, 10% are obstructive, and 50% are mixed [2]. Majority of participants in our study experienced mixed type of apnea with both central and obstructive elements. Our study did not predispose the participants to hypoxia. Firstly, it was not 20 apnea episodes per day. Apneas were recorded per 24 hours and sum of apneic spells during 4th to 7th day of therapy was depicted in the Table II (20 is total episodes). Any neonate with recurrent apneas, or apnea requiring bag and mask ventilation was considered for CPAP. Conventional mechanical ventilation was the backup option for infants who had significant apnea and bradycardia on methylxanthines and CPAP.

References

1. Shivakumar M, Jayashree, P, Muhammad N, Leslie ESL, Ramesh BY, Asha K, et al. Comparative efficacy and safety of caffeine and aminophylline for apnea of prematurity in preterm (£34 weeks) neonates: A randomized controlled trial. Indian Pediatr. 2017;54:279-83.

2. Martin RJ, Abu-Shaweesh JM. Control of breathing and neonatal apnea. Biol Neonate. 2005;87:288-95.


 

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