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Correspondence

Indian Pediatr 2015;52: 718-719

Partial Splenic Artery Embolization for the Management of Hypersplenism in Cirrhosis


Padmasani Venkat Ramanan and *Vidya Krishna

Department of Pediatrics, Sri Ramachandra Medical College,  Porur, Chennai, TN, India.
Email: [email protected]

     


A 10-year-old boy presented with extrapyramidal movements of 6 months duration. Wilson disease was confirmed by elevated 24 hours urinary copper excretion after
D-penicillamine challenge. Ultrasonography of the abdomen revealed features of cirrhosis with portal hypertension. He had pancytopenia (Hemoglobin 9.1 g /dL, total leukocyte count 2×109/L and platelet count 45×109/L. Prothrombin time was elevated (20s, INR 1.6), but the liver enzymes were normal. Patient was started on trihexyphenidyl, D-penicillamine and zinc. For management of pancytopenia due to the hypersplenism, partial splenic artery embolization was done. The procedure was done under conscious sedation using coils through right femoral access. Post-procedure angiogram revealed partial occlusion of splenic artery, slowing of splenic circulation and patent gastro-epiploic artery. After 48 hrs, the patient developed post-embolization syndrome, characterized by fever and pancreatitis (abdominal pain along with serum amylase 214 U/L and lipase 895 U/L) which was managed symptomatically with analgesics, antibiotics and intravenous fluids. The symptoms subsided over next three weeks. Ten days after the procedure, the total leukocyte count was 5.2x109/L and platelet count was 135x109/L.

Treatment of hypersplenism requires medical management of the primary disease. Splenectomy is associated with significant post-operative morbidity, increased risk of portal vein thrombosis, infections by encapsulated organisms and worsening hepatic encephalopathy when hypersplenism is due to cirrhosis. Partial splenic artery embolization (embolization of about 40-80% of the splenic tissue) is a better option as the risk of infections and worsening of liver function is reduced as some functioning splenic tissue is preserved. The rise in blood counts usually occurs within two weeks after the procedure. Post-embolization syndrome is the commonest complication encountered in more than 75% of the patients [1,2]. It begins after 24 to 48 hours and lasts for several days. It is self-limited and is managed conservatively. Other complications include pancreatitis, left sided pleural effusion, portal vein thrombosis and splenic abscess [3]. Mortality rate is around 0-6% [1].

Acknowledgements: Dr Santhosh Joseph, Professor and Head of Interventional Radiology and team for performing the procedure; Dr Shuba, Professor and Head of Pediatric Intensive Care Unit and team for post-operative management; and Dr Thambarasi, Junior resident for overall patient management.

References

1. Hadduck TA, McWilliams JP. Partial splenic artery embolization in cirrhotic patients. World J Radiol. 2014;6:160-8.

2. Smith M, Ray CE. Splenic artery embolization as an adjunctive procedure for portal hypertension. Semin Intervent Radiol. 2012;29:135-9.

3. Khurana A, Abddel Khalek M, Brown J, Barry B, Jaffe BM, Kandil E. Acute necrotizing pancreatitis following splenic artery embolization. Trop Gastroenterol. 2011;32:226-9. 


 

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