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Gaurav Gupta
Email:
[email protected]
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What are the causes of chronic cough in
pediatric outpatient practice? (Chest 2009 Jun 30 [Epub ahead of
print]) |
Children presenting with chronic cough are common to the primary care
physicians but data on the etiology are scant. The authors evaluated 40
children (5-12 years) with chronic cough (> 8 weeks duration) with no
obvious cause and referred by the primary care physicians. All patients
underwent an extensive multispeciality workup. Gastro-esophageal reflux
disease (27.5%); allergy (22.5%) and asthma (12.5%) accounted for >60% of
the likely etiological factors of chronic cough in children, besides
infection (5%) and aspiration (2.5%). Appropriate treatment for these
factors resulted in a significant improvement in cough.
Comment No ground breaking discovery here, however it may be
pertinent to try and remember how many times we look for these causes and
call for appropriate referrals in our outpatient practice.
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Can montelukast cause psychiatric
disorders in children? (Pharmacoe-pidemiol Drug Saf 2009 Jun 23 [Epub
ahead of print]) |
There have been concerns about the use of montelukast and adverse drug
reactions (ADRs) in children. The authors of this study analyzed all
reports of psychiatric disorders during treatment with montelukast in
children (<18 years) in the Swedish ADR database SWEDIS (1998-2007). A
total of 48 reports of psychiatric disorders in children during treatment
with montelukast were documented. Psychiatric disorders reported more than
once included nightmares (n = 15), unspecified anxiety (n =
11), aggressiveness (n = 11), sleep disorders (n = 10),
insomnia (n = 3), irritability (n = 3), hallucination (n
= 3), hyperactivity (n = 3), and personality disorder (n =
2). Time from exposure to ADR was less than 1 week. Psychiatric ADRs can
occur during montelukast treatment in children; further studies are needed
to establish the magnitude of the problem.
Comment This study raises an interesting
observation that should make us more open to evaluate the possible
‘unrelated’ side-effects of the newer drugs that we routinely prescribe.
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Does antibiotic use predispose to the
recurrence of acute otitis media? (BMJ 2009; 338: b2525). |
A primary care based, double blind, randomized, placebo controlled trial
with three year follow-up was conducted at 53 general practices in the
Netherlands. 168 children aged 6 months to 2 years with acute otitis media
received amoxicillin 40 mg/kg/day in three doses compared with placebo.
Acute otitis media recurred in 63% (47/75) of children in the amoxicillin
group and in 43% (37/86) of the placebo group.
Comment Recurrent acute otitis media occurred more
often in the children originally treated with amoxicillin. This is another
argument for judicious use of antibiotics in children.
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Managing an ingrown toe nail (Eur
J Pediatr Surg 2009 Jun 30 [Epub ahead of print]) |
Ingrowing toenails cause significant discomfort for children and adults
alike. Where conservative treatment fails, a surgical approach is usually
adopted. Many surgical procedures have been described with varying
complexity and outcome. The authors report a novel, simple technique which
involves wedge excision of the ingrowing nail, and bipolar diathermy of
the nail bed. 353 procedures were carried out on 302 patients during the
study period. The re-operation rate for recurrence is 9.9%, which compares
favorably with other techniques.
Comment: A simple easily available intervention
that has the potential to reduce the recurrence rate of surgery in this
very painful condition.
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