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Correspondence

Indian Pediatr 2016;53: 351

Inappropriately Small Sample for Studying Adverse Events Following Immunization
(Author’s Reply)

 

Rajeev Zachariah Kompithra

Email: [email protected]

 

 


We agree that our study [1] was not powered to detect rare adverse events following immunization. Our study was powered to detect illnesses with a 1% or higher prevalence. This was sufficient to detect the increased risk of fever after vaccination. We also extended the study to examine the common childhood illnesses before and after immunization using a risk interval approach. Given that there is no description of these conditions following immunization visits with multiple vaccines in routine clinical practice, we believe that our data is useful for the community of practicing pediatricians and those interested in immunization.

We also appreciate the editorial that accompanied our paper which highlighted that "the study could be an appropriate starting point for more research to generate comparable data from public and private sector and different geographic locations in the country" [2].

References

1. Kompithra RZ, Sarkar R, Mathew LG, Muliyil J, Kang G. Study of common illnesses before and after vaccination: a risk interval approach. Indian Pediatr. 2015;52:933-8.

2. Lahariya C. Strengthening the health systems for evidence-informed policy making. Indian Pediatr. 2015;52:931-2.

 

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